Chemistry:DCW234

Short description: Chemical compound

DCW234

Clinical data
Other names	Butyl 4-(butyryloxy)benzoate
Identifiers
IUPAC name butyl 4-butanoyloxybenzoate
CAS Number	723759-26-0
PubChem CID	1729084
ChemSpider	1371590
Chemical and physical data
Formula	C15H20O4
Molar mass	264.321 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCOC(=O)C1=CC=C(C=C1)OC(=O)CCC
InChI InChI=1S/C15H20O4/c1-3-5-11-18-15(17)12-7-9-13(10-8-12)19-14(16)6-4-2/h7-10H,3-6,11H2,1-2H3 Key:LMJDPYAJKHNPHR-UHFFFAOYSA-N

DCW234, also known as butyl 4-(butyryloxy)benzoate, is a synthetic nonsteroidal estrogen and a selective agonist of the ERβ. It shows modest selectivity in terms of affinity and transactivation for the ERβ over the ERα. Its affinity for the ERβ was 3.43 μM and for the ERα was 22.5 μM, while it activated the ERβ and ERα with EC₅₀ values of 1.71–2.5 μM and 19.8–22.5 μM, respectively. As such, its binding selectivity for the ERβ over the ERα was 7-fold and its functional selectivity for the ERβ over the ERα was between 10- and 13-fold.

See also

• Diarylpropionitrile