Chemistry:Zuclomifene
From HandWiki
Short description: Chemical compound
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| Other names | Zuclomiphene; trans-Clomifene; Transclomiphene; (Z)-Clomifene; ICI-46476; RMI-16312; Zuclomifene citrate; Zuclomiphene citrate |
| Routes of administration | Oral |
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| Formula | C26H28ClNO |
| Molar mass | 405.97 g·mol−1 |
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Zuclomifene (INN; or zuclomiphene (USAN)) is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that was never marketed.[1][2][3][4] It is one of the two stereoisomers of clomifene, which itself is a mixture of 38% zuclomifene and 62% enclomifene.[4] Zuclomifene is the (Z)-stereoisomer of clomifene, while enclomifene is the (E)-stereoisomer.[1][2] Whereas zuclomifene is described as mildly estrogenic, enclomifene is described as antiestrogenic.[4][5] In accordance, unlike enclomifene, zuclomifene is antigonadotropic due to activation of the estrogen receptor and reduces testosterone levels in men.[4] It is also about five times more potent than enclomifene in inducing ovulation.[5]
References
- ↑ 1.0 1.1 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 298–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA298.
- ↑ 2.0 2.1 Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999. pp. 79–. ISBN 978-0-7514-0499-9. https://books.google.com/books?id=mqaOMOtk61IC&pg=PA79.
- ↑ "Enclomifene - Repros Therapeutics". AdisInsight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800019625.
- ↑ 4.0 4.1 4.2 4.3 "Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men". IDrugs 12 (2): 109–119. February 2009. PMID 19204885. https://www.researchgate.net/publication/23995306.
- ↑ 5.0 5.1 "Selective Estrogen Receptors Modulators". Analogue-based Drug Discovery III. John Wiley & Sons. 15 October 2012. pp. 5–. ISBN 978-3-527-65110-8. https://books.google.com/books?id=BP2Bo11gTOMC&pg=SA5-PA58.
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