Biology:Interleukin 10 receptor, alpha subunit

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its human gene.

IL10RA has also been designated CDw210a (cluster of differentiation w210a).

Function

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of myeloid progenitor cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

Interactions

Interleukin 10 receptor, alpha subunit has been shown to interact with:

• Interleukin 10 and
• Janus kinase 1.

Further reading

• "The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes". J. Interferon Cytokine Res. 19 (6): 563–73. 1999. doi:10.1089/107999099313695. PMID 10433356. https://zenodo.org/record/1235223. 
• "The functional characterization of interleukin-10 receptor expression on human natural killer cells". Blood 85 (12): 3577–85. 1995. doi:10.1182/blood.V85.12.3577.bloodjournal85123577. PMID 7540068. 
• "Functional regions of the mouse interleukin-10 receptor cytoplasmic domain". Mol. Cell. Biol. 15 (9): 5043–53. 1995. doi:10.1128/mcb.15.9.5043. PMID 7544437. 
• "Characterization of recombinant extracellular domain of human interleukin-10 receptor". J. Biol. Chem. 270 (21): 12906–11. 1995. doi:10.1074/jbc.270.21.12906. PMID 7759550. 
• "The human interleukin-10 receptor gene maps to chromosome 11q23.3". Hum. Genet. 95 (1): 99–101. 1995. doi:10.1007/BF00225083. PMID 7814035. 
• "Expression cloning and characterization of a human IL-10 receptor". J. Immunol. 152 (4): 1821–9. 1994. doi:10.4049/jimmunol.152.4.1821. PMID 8120391. 
• "A receptor for interleukin 10 is related to interferon receptors". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11267–71. 1994. doi:10.1073/pnas.90.23.11267. PMID 8248239. Bibcode: 1993PNAS...9011267H. 
• "Characterization of interleukin-10 receptors on human and mouse cells". J. Biol. Chem. 268 (28): 21053–9. 1993. doi:10.1016/S0021-9258(19)36892-9. PMID 8407942. 
• "Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements". J. Biol. Chem. 271 (24): 13968–75. 1996. doi:10.1074/jbc.271.24.13968. PMID 8662928. 
• "Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor". Protein Sci. 5 (10): 1955–62. 1997. doi:10.1002/pro.5560051001. PMID 8897595. 
• "Identification and functional characterization of a second chain of the interleukin-10 receptor complex". EMBO J. 16 (19): 5894–903. 1997. doi:10.1093/emboj/16.19.5894. PMID 9312047. 
• "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization". Eur. J. Biochem. 262 (1): 134–41. 1999. doi:10.1046/j.1432-1327.1999.00363.x. PMID 10231374. 
• "Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes". Inflamm. Res. 48 (10): 539–43. 1999. doi:10.1007/s000110050500. PMID 10563471. 
• "Regulatory activity of autocrine IL-10 on dendritic cell functions". J. Immunol. 166 (7): 4312–8. 2001. doi:10.4049/jimmunol.166.7.4312. PMID 11254683. 
• "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity 15 (1): 35–46. 2001. doi:10.1016/S1074-7613(01)00169-8. PMID 11485736. 
• "Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10". J. Immunol. 167 (4): 2312–22. 2001. doi:10.4049/jimmunol.167.4.2312. PMID 11490020. 
• "IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase". J. Immunol. 167 (8): 4436–42. 2001. doi:10.4049/jimmunol.167.8.4436. PMID 11591769. 
• "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D 57 (Pt 12): 1908–11. 2002. doi:10.1107/S0907444901016249. PMID 11717514. 
• "Cutting edge: immune cells as sources and targets of the IL-10 family members?". J. Immunol. 168 (11): 5397–402. 2002. doi:10.4049/jimmunol.168.11.5397. PMID 12023331. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.