Biology:OX40 ligand
| tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa) | |
|---|---|
| Identifiers | |
| Symbol | TNFSF4 |
| Alt. symbols | TXGP1, OX-40L, gp34, CD252 |
| NCBI gene | 7292 |
| HGNC | 11934 |
| OMIM | 603594 |
| RefSeq | NM_003326 |
| UniProt | P23510 |
| Other data | |
| Locus | Chr. 1 q25 |
OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as DC2s (a subtype of dendritic cells),[1] macrophages,[2] and activated B lymphocytes.[3]
The OX40 molecule, conversely, is present on the surface of activated T lymphocytes (mainly CD4+ T cells),[4] but also on NK cells,[5] NKT cells,[6] and neutrophils.[6] The ligation of OX40-OX40L is a source of survival signal for T cells[6] and enables the development of memory T cells.[7] Signaling through these two molecules also leads to polarization towards Th2 immune response even in an environment with low levels of IL-4 cytokine.[1][8]
OX40L is also present on the surface of many non-immune cells, for example, endothelial cells[9] and smooth muscle cells.[10]
The surface expression of OX40L is induced by many pro-inflammatory mediators, such as TNF-α, e.g. produced by mast cells,[11] IFN-γ[12] and PGE2 (prostaglandin E2).[13]
OX40L has also been designated CD252 (cluster of differentiation 252).[14]
Various single-nucleotide polymorphisms (SNPs) of the OX40L gene have been identified. For some of them association with systemic lupus erythematosus has been reported.[15] No association with occurrence of atherosclerosis has been found.[16]
References
- ↑ 1.0 1.1 "Immune regulation by helminth parasites: cellular and molecular mechanisms". Nature Reviews. Immunology 3 (9): 733–44. September 2003. doi:10.1038/nri1183. PMID 12949497. http://www.era.lib.ed.ac.uk/bitstream/1842/465/1/Maizels_%26_Yazdanbakhsh.pdf.
- ↑ "The upregulated expression of OX40/OX40L and their promotion of T cells proliferation in the murine model of asthma". Journal of Thoracic Disease 6 (7): 979–87. July 2014. doi:10.3978/j.issn.2072-1439.2014.06.34. PMID 25093096.
- ↑ "Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells". Immunity 2 (5): 507–21. May 1995. doi:10.1016/1074-7613(95)90031-4. PMID 7749983.
- ↑ "Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses". European Journal of Immunology 32 (12): 3617–27. December 2002. doi:10.1002/1521-4141(200212)32:12<3617::AID-IMMU3617>3.0.CO;2-M. PMID 12516549.
- ↑ "Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking". Scientific Reports 8 (1): 2278. February 2018. doi:10.1038/s41598-018-20656-y. PMID 29396470. Bibcode: 2018NatSR...8.2278T.
- ↑ 6.0 6.1 6.2 "Control of immunity by the TNFR-related molecule OX40 (CD134)". Annual Review of Immunology 28 (1): 57–78. March 2010. doi:10.1146/annurev-immunol-030409-101243. PMID 20307208.
- ↑ "CD40L expression permits CD8+ T cells to execute immunologic helper functions". Blood 122 (3): 405–12. July 2013. doi:10.1182/blood-2013-02-483586. PMID 23719298.
- ↑ Alt, Frederick W; Austen, K Frank (2009). Advances in immunology. 101. Amsterdam: Academic Press. ISBN 978-0080888330. OCLC 647803349.
- ↑ "The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells". The Journal of Experimental Medicine 183 (5): 2185–95. May 1996. doi:10.1084/jem.183.5.2185. PMID 8642328.
- ↑ "Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: a possible role in asthma?". The Journal of Allergy and Clinical Immunology 113 (4): 683–9. April 2004. doi:10.1016/j.jaci.2003.12.311. PMID 15100674.
- ↑ "Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF". Journal of Immunology 176 (4): 2238–48. February 2006. doi:10.4049/jimmunol.176.4.2238. PMID 16455980.
- ↑ "Expression of OX40 ligand in microglia activated by IFN-gamma sustains a protective CD4+ T-cell response in vitro". Cellular Immunology 251 (2): 86–92. February 2008. doi:10.1016/j.cellimm.2008.04.002. PMID 18485335.
- ↑ "Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells". Blood 113 (11): 2451–60. March 2009. doi:10.1182/blood-2008-05-157123. PMID 19029446. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-107550.
- ↑ Universal protein resource accession number P23510 for "TNFSF4 - Tumor necrosis factor ligand superfamily member 4 - Homo sapiens (Human) " at UniProt.
- ↑ "Association of TNFSF4 polymorphisms with systemic lupus erythematosus: a meta-analysis". Modern Rheumatology 23 (4): 686–93. July 2013. doi:10.3109/s10165-012-0708-8. PMID 22850862.
- ↑ "Absence of association between atherosclerotic cerebral infarction and TNFSF4/TNFRSF4 single nucleotide polymorphisms rs1234313, rs1234314 and rs17568 in a Chinese population". The Journal of International Medical Research 42 (2): 436–43. April 2014. doi:10.1177/0300060514521154. PMID 24595151.
External links
- OX40L+Protein at the US National Library of Medicine Medical Subject Headings (MeSH)
- TNFSF4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
