Chemistry:Hydrocotarnine

Hydrocotarnine, used in combination with oxycodone under the trade name Pavinal (Japan), is a substituted tetrahydroisoquinoline alkaloid, non-narcotic analgesic. It is also classified as a cyclized phenylethylamine. Hydrocotarnine is a drug that is primarily used in combination with oxycodone to enhance its analgesic effect. The mechanism of action of hydrocotarnine is not fully understood, but it is known that it is one of the non-narcotic alkaloids of the poppy Papaver somniferum. Combinations of oxycodone and hydrocotarnine are taken orally and by injection.^[1]^[2]^[3]^[4]^[5]^[6]^[7] Hydrocotarnine is reported as a natural product present in Corydalis ophiocarpa, Corydalis ochotensis, and Corydalis heterocarpa var. japonica.^[8]

References

↑ "NCATS Inxight Drugs — HYDROCOTARNINE" (in en). https://drugs.ncats.io/drug/G22L6JNE61.
↑ Tittarelli, Roberta; Gismondi, Angelo; Di Marco, Gabriele; Mineo, Federico; Vernich, Francesca; Russo, Carmelo; Marsella, Luigi Tonino; Canini, Antonella (2022-04-27). "Forensic Application of Genetic and Toxicological Analyses for the Identification and Characterization of the Opium Poppy (Papaver somniferum L.)". Biology 11 (5): 672. doi:10.3390/biology11050672. ISSN 2079-7737. PMID 35625400.
↑ Yoshimoto, Tetsusuke; Hisada, Atsuo; Yomiya, Kinomi; Tomiyasu, Shiro; Hasegawa, Toru; Murakami, Satoshi; Matoba, Motohiro (2010). "[Efficacy and safety of compound oxycodone injection for cancer pain relief-a multicenter survey of prescriptions]". Gan to Kagaku Ryoho. Cancer & Chemotherapy 37 (5): 871–878. ISSN 0385-0684. PMID 20495318.
↑ Yoshimoto, Tetsusuke; Hisada, Atsuo; Hasegawa, Toru; Nozaki, Yasuhiro; Matoba, Motohiro; Symptom Control Research Group SCORE-G (2009). "[Efficacy and safety of continuous subcutaneous injection of the compound oxycodone in cancer pain management: the first 4-year audit]". Gan to Kagaku Ryoho. Cancer & Chemotherapy 36 (10): 1683–1689. ISSN 0385-0684. PMID 19838028.
↑ Kokubun, Hideya; Nakamura, Kazuyo; Fukawa, Misako; Matoba, Motohiro; Hoka, Sumio; Yago, Kazuo (2007). "[Conversion ratio between intravenous oxycodone/hydrocotarnine and sustained-release oral oxycodone in patients with cancer pain]". Gan to Kagaku Ryoho. Cancer & Chemotherapy 34 (13): 2255–2258. ISSN 0385-0684. PMID 18079625.
↑ Hughes, Lewis Thomas; Raftery, David; Coulter, Paul; Laird, Barry; Fallon, Marie (2022). "Use of opioids in patients with cancer with hepatic impairment-a systematic review". BMJ Supportive & Palliative Care 12 (2): 152–157. doi:10.1136/bmjspcare-2021-003065. ISSN 2045-4368. PMID 34470772.
↑ Sano, Tomomi; Akagi, Toru; Yokote, Nobuaki; Shuto, Chio; Kudo, Naoko; Miura, Kousuke; Murakami, Satoshi; Saito, Osamu et al. (2012). "[Retrospective study on intravenous compound injection of cancer pain patients with oxycodone and hydrocotarnine preparation in comparison with subcutaneous administration]". Gan to Kagaku Ryoho. Cancer & Chemotherapy 39 (5): 769–775. ISSN 0385-0684. PMID 22584329.
↑ Template:Cite PubChem

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[1] "NCATS Inxight Drugs — HYDROCOTARNINE" (in en). https://drugs.ncats.io/drug/G22L6JNE61.

[2] Tittarelli, Roberta; Gismondi, Angelo; Di Marco, Gabriele; Mineo, Federico; Vernich, Francesca; Russo, Carmelo; Marsella, Luigi Tonino; Canini, Antonella (2022-04-27). "Forensic Application of Genetic and Toxicological Analyses for the Identification and Characterization of the Opium Poppy (Papaver somniferum L.)". Biology 11 (5): 672. doi:10.3390/biology11050672. ISSN 2079-7737. PMID 35625400.

[3] Yoshimoto, Tetsusuke; Hisada, Atsuo; Yomiya, Kinomi; Tomiyasu, Shiro; Hasegawa, Toru; Murakami, Satoshi; Matoba, Motohiro (2010). "[Efficacy and safety of compound oxycodone injection for cancer pain relief-a multicenter survey of prescriptions]". Gan to Kagaku Ryoho. Cancer & Chemotherapy 37 (5): 871–878. ISSN 0385-0684. PMID 20495318.

[4] Yoshimoto, Tetsusuke; Hisada, Atsuo; Hasegawa, Toru; Nozaki, Yasuhiro; Matoba, Motohiro; Symptom Control Research Group SCORE-G (2009). "[Efficacy and safety of continuous subcutaneous injection of the compound oxycodone in cancer pain management: the first 4-year audit]". Gan to Kagaku Ryoho. Cancer & Chemotherapy 36 (10): 1683–1689. ISSN 0385-0684. PMID 19838028.

[5] Kokubun, Hideya; Nakamura, Kazuyo; Fukawa, Misako; Matoba, Motohiro; Hoka, Sumio; Yago, Kazuo (2007). "[Conversion ratio between intravenous oxycodone/hydrocotarnine and sustained-release oral oxycodone in patients with cancer pain]". Gan to Kagaku Ryoho. Cancer & Chemotherapy 34 (13): 2255–2258. ISSN 0385-0684. PMID 18079625.

[6] Hughes, Lewis Thomas; Raftery, David; Coulter, Paul; Laird, Barry; Fallon, Marie (2022). "Use of opioids in patients with cancer with hepatic impairment-a systematic review". BMJ Supportive & Palliative Care 12 (2): 152–157. doi:10.1136/bmjspcare-2021-003065. ISSN 2045-4368. PMID 34470772.

[7] Sano, Tomomi; Akagi, Toru; Yokote, Nobuaki; Shuto, Chio; Kudo, Naoko; Miura, Kousuke; Murakami, Satoshi; Saito, Osamu et al. (2012). "[Retrospective study on intravenous compound injection of cancer pain patients with oxycodone and hydrocotarnine preparation in comparison with subcutaneous administration]". Gan to Kagaku Ryoho. Cancer & Chemotherapy 39 (5): 769–775. ISSN 0385-0684. PMID 22584329.

[8] Template:Cite PubChem

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