Chemistry:Meso-Butestrol
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Short description: Chemical compound
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| Other names | meso-Butoestrol; SC-3402; mbE3; meso-2,3-bis(4-Hydroxyphenyl)-n-butane |
| Drug class | Nonsteroidal estrogen |
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| Formula | C16H18O2 |
| Molar mass | 242.318 g·mol−1 |
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meso-Butestrol (developmental code name SC-3402), also known as 2,3-bis(4-hydroxyphenyl)butane, is a synthetic nonsteroidal estrogen which was never marketed.[1][2][3][4][5][6][7] It is a so-called "short-acting" or "impeded" estrogen.[1][2][3][5][4][6][7] meso-Butestrol is structurally related to diethylstilbestrol and other stilbestrols.[8] The fully potent counterpart to meso-butestrol is meso-hexestrol, analogously to the relationship of dimethylstilbestrol to diethylstilbestrol.[3]
See also
References
- ↑ 1.0 1.1 "The oestrogenic potency in the mouse of several substances closely related to diethylstilboestrol and meso-hexoestrol". J. Endocrinol. 45 (1): 9–15. September 1969. doi:10.1677/joe.0.0450009. PMID 5347383.
- ↑ 2.0 2.1 "Two modes of interaction between oestrogen and anti-oestrogen". Acta Endocrinol. 64 (1): 47–58. May 1970. doi:10.1530/acta.0.0640047. PMID 5468795.
- ↑ 3.0 3.1 3.2 "Structure-activity relationships of anti-oestrogens with regard to interaction with 17-beta-oestradiol in the mouse uterus and vagina". Acta Endocrinol. 66 (3): 431–47. March 1971. doi:10.1530/acta.0.0660431. PMID 5107780.
- ↑ 4.0 4.1 "The Allen-Doisy test for estrogens reinvestigated". Steroids 17 (6): 653–61. June 1971. doi:10.1016/0039-128x(71)90081-x. PMID 5104534.
- ↑ 5.0 5.1 "The agonistic and antagonistic effects of short acting estrogens: a review". Pharmacol. Ther. 21 (3): 429–53. 1983. doi:10.1016/0163-7258(83)90063-3. PMID 6356176.
- ↑ 6.0 6.1 "Antioestrogens. A review". Clin. Endocrinol. (Oxf) 4 (5): 551–72. September 1975. doi:10.1111/j.1365-2265.1975.tb01568.x. PMID 170029.
- ↑ 7.0 7.1 "The mitogenic action of oestrogens in the vaginal epithelium of the ovariectomized mouse". J. Endocrinol. 20 (3): 173–86. May 1960. doi:10.1677/joe.0.0200173. PMID 14421704.
- ↑ "The oestrogenic and anti-oestrogenic activity of compounds related to diethylstilboestrol". Acta Endocrinol. 45 (4_Suppl): SUPPL90:61–9. 1964. doi:10.1530/acta.0.045s061. PMID 14117596.
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