Chemistry:NS-11394
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Short description: Chemical compound
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| Formula | C23H19N3O |
| Molar mass | 353.425 g·mol−1 |
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NS-11394 is a drug which acts as a subtype-selective positive allosteric modulator at GABAA receptors, with selectivity for the α3 and α5 subtypes.[1][2] It has been researched as an analgesic for use in chronic or neuropathic pain.[3]
References
- ↑ "Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain". The Journal of Pharmacology and Experimental Therapeutics 327 (3): 969–81. December 2008. doi:10.1124/jpet.108.144568. PMID 18791060.
- ↑ "NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy". The Journal of Pharmacology and Experimental Therapeutics 327 (3): 954–68. December 2008. doi:10.1124/jpet.108.138859. PMID 18791063.
- ↑ "Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets". Trends in Pharmacological Sciences 30 (9): 453–9. September 2009. doi:10.1016/j.tips.2009.06.004. PMID 19729210.
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