Chemistry:TP-003
From HandWiki
TP-003 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.
TP-003 is a positive allosteric modulator at the benzodiazepine binding site of GABAA receptors.[1] It possesses relative selectivity for benzodiazepine sites on α3-containing GABAA receptors, which are thought to contribute to the anxiolytic effects of benzodiazepines (in tandem with those containing α2 subunits).[2] It has modest anticonvulsant activity although less than that of diazepam.[3]
See also
References
- ↑ "TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors". Neuropharmacology 143: 71–78. 2018. doi:10.1016/j.neuropharm.2018.09.026. PMID 30240781.
- ↑ "GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism". Annual Review of Pharmacology and Toxicology 54: 483–507. 2013-10-23. doi:10.1146/annurev-pharmtox-011613-135947. PMID 24160694.
- ↑ "Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands". Journal of Psychopharmacology 21 (4): 384–91. Jun 2007. doi:10.1177/0269881106067255. PMID 17092983.
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