Chemistry:TP-003
From HandWiki
Short description: Chemical compound
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| Chemical and physical data | |
| Formula | C23H16F3N3O |
| Molar mass | 407.396 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
TP-003 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a positive allosteric modulator at the benzodiazepine binding site of GABAA receptors.[1] It has modest anticonvulsant activity although less than that of diazepam.[2]
See also
References
- ↑ "TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors". Neuropharmacology 143: 71–78. 2018. doi:10.1016/j.neuropharm.2018.09.026. PMID 30240781.
- ↑ "Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands". Journal of Psychopharmacology 21 (4): 384–91. Jun 2007. doi:10.1177/0269881106067255. PMID 17092983.
 |  |
