Chemistry:TP-13
From HandWiki
Short description: Chemical compound
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| Formula | C19H19N7O |
| Molar mass | 361.409 g·mol−1 |
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TP-13 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a subtype-selective partial agonist at GABAA receptors, binding selectively to GABAA receptor complexes bearing α2 and α3 subunits.[1] It has modest anticonvulsant activity although less than that of diazepam,[2] and its main effect is likely to be selective anxiolytic action, as seen with other related α2/3-preferring agonists such as L-838,417.
References
- ↑ "Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour". Neuropharmacology 46 (2): 171–8. February 2004. doi:10.1016/j.neuropharm.2003.09.004. PMID 14680756.
- ↑ "Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands". Journal of Psychopharmacology 21 (4): 384–91. June 2007. doi:10.1177/0269881106067255. PMID 17092983.
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