Chemistry:Thiobarbital

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Short description: Chemical compound
Thiobarbital
Thiobarbital.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC8H12N2O2S
Molar mass200.259 g·mol−1
3D model (JSmol)
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Thiobarbital is a drug which is a barbiturate derivative. It is the thiobarbiturate analogue of barbital.

Synthesis

Thiobarbital synthesis:[1][2]

It is of note that although the drug can be prepared by the above route (cf e.g. thialbarbital), reaction of barbital with phosphorus pentasulfide constitutes an alternative route to thiobarbital.

References

  1. "Ueber C-Dialkylbarbitursäuren und über die Ureïde der Dialkylessigsäuren". Justus Liebig's Annalen der Chemie 335 (3): 334–368. 1904. doi:10.1002/jlac.19043350303. https://zenodo.org/record/1427545. 
  2. "45. The action of phosphorus pentasulphide on barbituric acids". Journal of the Chemical Society (Resumed): 124. 1944. doi:10.1039/JR9440000124.