Chemistry:DS-1 (drug)
From HandWiki
Short description: Chemical compound
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| Formula | C18H10Br2ClN3OS |
| Molar mass | 511.62 g·mol−1 |
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DS-1 is a drug from the imidazopyridine family, which is the first drug developed that acts as a GABAA receptor positive allosteric modulator (PAM) selective for the α4β3δ subtype, which is not targeted by other GABAA receptor PAMs such as the benzodiazepines or other nonbenzodiazepine drugs. Novel selective drugs such as DS-1 are useful in the study of this receptor subtype.[1][2][3]
See also
References
- ↑ "Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus". Neuropharmacology 56 (1): 182–189. January 2009. doi:10.1016/j.neuropharm.2008.08.004. PMID 18762200.
- ↑ "Structure-Function Evaluation of Imidazopyridine Derivatives Selective for δ-Subunit-Containing γ-Aminobutyric Acid Type A (GABAA) Receptors". Journal of Medicinal Chemistry 61 (5): 1951–1968. March 2018. doi:10.1021/acs.jmedchem.7b01484. PMID 29451785.
- ↑ "GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators". European Journal of Medicinal Chemistry 171: 434–461. June 2019. doi:10.1016/j.ejmech.2019.03.043. PMID 30928713.
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