Chemistry:Tetrabamate
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Short description: Combination drug
| Combination of | |
|---|---|
| Febarbamate | Carbamate, barbiturate |
| Difebarbamate | Carbamate, barbiturate |
| Phenobarbital | Barbiturate |
| Identifiers | |
| ChEMBL | |
Tetrabamate (Atrium, G Tril, Sevrium) is a combination drug formulation of febarbamate, difebarbamate, and phenobarbital which was marketed in France and Spain and was used to treat anxiety and alcohol withdrawal-associated muscle tremors, agitation, and depression.[1][2][3][4] It was largely, but not completely discontinued on April 4, 1997, after over 30 years of use due to reports of hepatitis and acute liver failure.[3][4][5][6] The decision to restrict the use of the drug had been long-awaited.[clarification needed][6]
References
- ↑ Index nominum 2000: international drug directory. Taylor & Francis US. 2000. pp. 333 & 427. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA333. Retrieved 26 November 2011.
- ↑ "Drug-Induced Liver Disease". Schiff's Diseases of the Liver. John Wiley and Sons. 19 October 2011. pp. 703–783. doi:10.1002/9781119950509.ch27. ISBN 978-1-119-95048-6. https://books.google.com/books?id=HsxFSx_B4sUC&pg=PT2276. Retrieved 26 November 2011.
- ↑ 3.0 3.1 "[Acute liver failure following tetrabamate]" (in de). Schweizerische Medizinische Wochenschrift 125 (19): 965–969. May 1995. PMID 7761807.
- ↑ 4.0 4.1 Consolidated list of products whose consumption and/or sale have been banned, withdrawn, severely restricted or not approved by governments. United Nations Publications. 2003. pp. 259. ISBN 978-92-1-130230-1. https://books.google.com/books?id=leVCukUgNlsC&pg=PA259. Retrieved 26 November 2011.[yes|permanent dead link|dead link}}]
- ↑ "Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate". Journal of Hepatology 21 (6): 1075–1079. December 1994. doi:10.1016/s0168-8278(05)80620-8. PMID 7699230.
- ↑ 6.0 6.1 "Severe hepatitis due to Atrium". Prescrire International 10 (55): 150. October 2001. PMID 11824432.
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