Chemistry:Pipequaline
From HandWiki
Short description: Chemical compound
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| Formula | C22H24N2 |
| Molar mass | 316.448 g·mol−1 |
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Pipequaline (INN) (developmental code name PK-8165) is an anxiolytic drug that was never marketed.[1] It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic.[2][3][4]
Pipequaline acts as a non-selective GABAA receptor partial agonist.[5][6][7] While its profile of anxiolytic effects without sedation would appear to have potential medical applications, pipequaline has never been developed for medical use and is currently only used in scientific research.
See also
References
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 986–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA986.
- ↑ "Evaluation of the sedative properties of PK 8165 (pipequaline), a benzodiazepine partial agonist, in normal subjects". International Clinical Psychopharmacology 1 (1): 24–35. January 1986. doi:10.1097/00004850-198601000-00004. PMID 3559150.
- ↑ "The ability of PK 8165, a quinoline derivative, to reduce responses to a stressful situation in a double-blind study in man". Neuropharmacology 25 (3): 275–81. March 1986. doi:10.1016/0028-3908(86)90252-2. PMID 3703176.
- ↑ "The effects on memory of pipequaline, alone or in combination with diazepam". Psychopharmacology 95 (3): 386–9. 1988. doi:10.1007/BF00181953. PMID 3137626.
- ↑ "Pharmacological evidence that PK 8165 behaves as a partial agonist of brain type benzodiazepine receptors". Archives Internationales de Pharmacodynamie et de Therapie 271 (2): 189–97. October 1984. PMID 6095778.
- ↑ "Biochemical evidence that 2-phenyl-4[(4-piperidinyl) ethyl]quinoline, a quinoline derivative with pure anticonflict properties, is a partial agonist of benzodiazepine receptors". Neuropharmacology 23 (10): 1129–36. October 1984. doi:10.1016/0028-3908(84)90229-6. PMID 6097832.
- ↑ "Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat". Neuropharmacology 26 (9): 1337–42. September 1987. doi:10.1016/0028-3908(87)90096-7. PMID 2823163.
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