Biology:Posovolone
From HandWiki
Short description: Chemical compound
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| Other names | CO-134444; Co 134444; V-134444; 3β-Hydroxy-21-(1H-imidazol-1-yl)-3α-(methoxymethyl)-5α-pregnan-20-one |
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| Formula | C26H40N2O3 |
| Molar mass | 428.617 g·mol−1 |
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Posovolone (developmental code name Co 134444) is a synthetic neurosteroid which was under development as a sedative/hypnotic medication for the treatment of insomnia.[1][2] [3][4] It is orally active and acts as a GABAA receptor positive allosteric modulator.[1][5][2] In animals, posovolone shows anticonvulsant, anxiolytic-like, ataxic, and sleep-promoting effects and appeared to produce effects similar to those of pregnanolone.[2][6] Development of the agent was started by 1999 and appears to have been discontinued by 2007.[1][6] In 2021, an INN was registered for posovolone with the descriptor of "antidepressant".[5] Posovolone was originally developed by Purdue Pharma.[1]
See also
References
- ↑ 1.0 1.1 1.2 1.3 "CO 134444 - AdisInsight". https://adisinsight.springer.com/drugs/800013177.
- ↑ 2.0 2.1 2.2 "Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid". Psychopharmacology (Berl) 155 (3): 285–91. May 2001. doi:10.1007/s002130100695. PMID 11432691.
- ↑ "Interaction of steroids with the GABA(A) receptor". Curr Top Med Chem 2 (8): 887–902. August 2002. doi:10.2174/1568026023393570. PMID 12171578.
- ↑ "Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor". Neurobiol Stress 12: 100207. May 2020. doi:10.1016/j.ynstr.2019.100207. PMID 32435660.
- ↑ 5.0 5.1 https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl126.pdf#page=137 [bare URL PDF]
- ↑ 6.0 6.1 "Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids". J Pharmacol Exp Ther 291 (3): 1317–23. December 1999. PMID 10565857.
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