Chemistry:List of investigational sleep drugs

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This is a list of investigational sleep drugs, or drugs for the treatment of sleep disorders that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Insomnia

GABA_A receptor potentiators

• EVT-201 – GABA_A receptor positive allosteric modulator[1]
• Lorediplon (GF-015535-00) – GABA_A receptor positive allosteric modulator [2]
• Zuranolone (SAGE-217) – GABA_A receptor positive allosteric modulator [3]

Orexin receptor antagonists

• Seltorexant (MIN-202, JNJ,42847922, JNJ-922) – selective OX₂ receptor antagonist [4]
• Vornorexant (ORN-0829, TS-142) – dual OX₁ and OX₂ receptor antagonist [5]

Melatonin receptor agonists

• Piromelatine (Neu-P11) – melatonin receptor agonist and 5-HT_1A and 5-HT_1D receptor agonist [6]

Nociceptin receptor agonists

• Sunobinop (IMB-115, IT-1315, S-117957, V-117957) – nociceptin receptor agonist [7][8]

Hypersomnia/narcolepsy

Orexin receptor agonists

• Danavorexton (TAK-925) – OX₂ receptor-selective agonist via IV infusion[9]
• TAK-994 – OX₂ receptor agonist pill (orally available)[10]

Monoaminergics

• Flecainide/modafinil (THN-102) – modafinil (dopamine reuptake inhibitor) and flecainide (antiarrhythmic) combination [11]
• Mazindol controlled release (NLS-1001, NLS-1) – norepinephrine-predominant serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI)[12]
• Reboxetine (AXS-12) – norepinephrine reuptake inhibitor (NRI) [13]

GHB receptor agonists

• FT-218 (sodium oxybate controlled release) – GHB and GABA_B receptor agonist [14]

GABA_A receptor inhibitors

• Pentylenetetrazole (BTD-001) – GABA_A receptor negative allosteric modulator [15]

See also

• List of investigational drugs