Chemistry:4-Fluoroestradiol
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| Other names | 4-FE2; 4-F-17β-E2; 4-Fluoro-17β-estradiol; 4-Fluoroestra-1,3,5-(10)-triene-3,17β-diol; NSC-94528 |
| Drug class | Estrogen |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C18H23FO2 |
| Molar mass | 290.378 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
4-Fluoroestradiol (4-FE2) is a synthetic estrogen and a derivative of estradiol which was never marketed.[1] It is specifically the 4-fluoro analogue of estradiol.[1] 4-Fluoroestradiol has 180 ± 43% of the affinity of estradiol for the estrogen receptor of rat uterine cytosol and shows potent uterotrophic activity similar to that of estradiol in mice and rats.[1][2] It has been labeled with fluorine-18 (18F) for potential use in medical imaging.[3][4][5]
See also
- 16α-Fluoroestradiol
References
- ↑ 1.0 1.1 1.2 "The role of 2-methoxyestrone in estrogen action". Journal of Steroid Biochemistry 19 (1B): 635–638. July 1983. doi:10.1016/0022-4731(83)90229-7. PMID 6310247.
- ↑ "Biological activities of 4-fluoro estrogen analogues". Journal of Steroid Biochemistry 19 (3): 1325–1328. September 1983. doi:10.1016/0022-4731(83)90158-9. PMID 6621038.
- ↑ "Studies in the rat with 18F-4-fluoro-oestradiol and 18F-4-fluoro-oestrone as potential prostate scanning agents: comparison with 125I-2-iodo-oestradiol and 125I-2,4-di-iodo-oestradiol". The International Journal of Applied Radiation and Isotopes 30 (11): 695–700. November 1979. doi:10.1016/0020-708x(79)90111-x. PMID 544526.
- ↑ "Radiolabeled steroidal estrogens in cancer research". Steroids 58 (6): 245–259. June 1993. doi:10.1016/0039-128x(93)90069-y. PMID 8212070.
- ↑ "Fluorinated steroids and their derivatives". Journal of Fluorine Chemistry 185: 48–85. 2016. doi:10.1016/j.jfluchem.2016.03.009. ISSN 0022-1139.
 |  |
