Chemistry:Estradiol 17β-benzoate

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Short description: Chemical compound
Estradiol 17β-benzoate
Estradiol 17β-benzoate.svg
Clinical data
Other namesE2-17B; ZYC30
Drug classEstrogen; Estrogen ester
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC25H28O3
Molar mass376.496 g·mol−1
3D model (JSmol)

Estradiol 17β-benzoate (E2-17B) is an estrogen and an estrogen ester—specifically, the C17β benzoate ester of estradiol—which was never marketed.[1][2][3] It is the C17β positional isomer of the better-known and clinically used estradiol ester estradiol benzoate (estradiol 3-benzoate; Progynon-B).[1] Estradiol 17β-benzoate was first described in the 1930s.[4]

See also

References

  1. 1.0 1.1 "[Chemistry and pharmacology of steroid hormone esters]" (in de). Zeitschrift Fur Vitamin-, Hormon- und Fermentforschung 9 (1–2): 97–143 contd. 1957. PMID 13531579. 
  2. "Neuroprotective effects of estratriene analogs: structure-activity relationships and molecular optimization". Drug Development Research 66 (2): 78–92. 2005. doi:10.1002/ddr.20047. ISSN 0272-4391. 
  3. "The assessment of non-feminizing estrogens for use in neuroprotection". Brain Research 1379: 61–70. March 2011. doi:10.1016/j.brainres.2010.11.058. PMID 21111714. 
  4. "Relative duration of action of various esters of oestrone, oestradiol and oestriol". The Biochemical Journal 31 (4): 579–585. April 1937. doi:10.1042/bj0310579. PMID 16746375.