Chemistry:L-687,384

From HandWiki

L-687,384 is a sigma receptor agonist, selective for the σ1 subtype,[1] as well as an NMDA antagonist.[2]

See also

Spipethiane[3]

References

  1. ↑ "Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors". Psychopharmacology 129 (3): 215–24. February 1997. doi:10.1007/s002130050183. PMID 9084059. 
  2. ↑ "The actions of L-687,384, a sigma receptor ligand, on NMDA-induced currents in cultured rat hippocampal pyramidal neurons". Neuroscience Letters 174 (2): 181–4. June 1994. doi:10.1016/0304-3940(94)90016-7. PMID 7526288. 
  3. ↑ Quaglia W, Giannella M, Piergentili A, Pigini M, Brasili L, Di Toro R, Rossetti L, Spampinato S, Melchiorre C. 1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand. J Med Chem. 1998 May 7;41(10):1557-60. doi: 10.1021/jm970740r. PMID 9572880.




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