Chemistry:Polydiethylstilbestrol phosphate
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Short description: Chemical compound
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| Other names | PSP; PDSP; Diethylstilbestrol polymer with phosphoric acid; (E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis(phenol) polymer with phosphoric acid |
| Routes of administration | Intramuscular injection |
| Drug class | Estrogen; Nonsteroidal estrogen; Estrogen ester |
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| Formula | (C18H19O4P)n |
Polydiethylstilbestrol phosphate (PSP, PDSP) is an estrogen medication which has been used in scientific research and has been studied for use in veterinary medicine as a livestock growth promoter.[1][2][3][4][5][6] It is a phosphate ester of diethylstilbestrol (DES) in the form of a polymer and is a polymeric form of fosfestrol (diethylstilbestrol diphosphate); PDSP acts as a long-lasting prodrug of DES.[1] It has similarities to polyestradiol phosphate and polyestriol phosphate.[1]
See also
References
- ↑ 1.0 1.1 1.2 "High Molecular Weight Enzyme Inhibitors. IV. Polymeric Phosphates of Synthetic Estrogens.". Acta Chem. Scand. 13 (5): 1011–1018. 1959. doi:10.3891/acta.chem.scand.13-1011. http://actachemscand.org/pdf/acta_vol_13_p1011-1018.pdf.
- ↑ "Autoradiographic Distribution Studies after Administration of a Macromolecular Synthetic Oestrogen (14C-Polydiethylstilboestrol Phosphate)". Acta Endocrinol. 43 (4): 571–80. August 1963. doi:10.1530/acta.0.0430571. PMID 14059878.
- ↑ "Distribution and Excretion of Radioactivity after Parenteral Administration of Radioactive Polydiethylstilbestrol Phosphate to Rats and a Cow". Proc. Soc. Exp. Biol. Med. 117 (2): 394–8. November 1964. doi:10.3181/00379727-117-29590. PMID 14233451.
- ↑ "Excretion of radioactivity by human subjects after ingestion of liver from cattle treated with labeled polydiethylstilbestrol phosphate". Proc. Soc. Exp. Biol. Med. 119 (4): 996–8. 1965. doi:10.3181/00379727-119-30359. PMID 5891085.
- ↑ "Distribution and excretion of 14C-labeled polydiethylstilbestrol phosphate in a steer". J. Anim. Sci. 26 (5): 1094–100. September 1967. doi:10.2527/jas1967.2651094x. PMID 6077168.
- ↑ "The veterinarian and intensive livestock production: humane considerations". Can. Vet. J. 13 (10): 229–33. October 1972. PMID 4562986.
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