Chemistry:Lasmiditan

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Short description: Chemical compound
Lasmiditan
Lasmiditan.svg
Clinical data
Pronunciation/læzˈmɪdɪtæn/
laz-MID-i-tan
Trade namesReyvow, Rayvow
Other namesCOL-144
AHFS/Drugs.comMonograph
MedlinePlusa620015
License data
Routes of
administration		By mouth, intravenous
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC19H18F3N3O2
Molar mass377.367 g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Lasmiditan, sold under the brand name Reyvow, is a medication used for the acute (active but short-term) treatment of migraine with or without aura (a sensory phenomenon or visual disturbance) in adults.[1] It is not useful for prevention.[1] It is taken by mouth.[1]

Common side effects include sleepiness, dizziness, tiredness, and numbness.[4][5]

Lasmiditan was approved in the United States in October 2019[4] and became available in February 2020.[6] It was developed by Eli Lilly.[4] The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.[7]

Pharmacology

Mechanism of action

Lasmiditan is a serotonin receptor agonist that, like the unsuccessful LY-334,370, selectively binds to the 5-HT1F receptor subtype. A number of triptans have been shown to act on this subtype as well, but only after their affinity for 5-HT1B and 5-HT1D has been made responsible for their anti-migraine activity.[8] The lack of affinity for these receptors might result in fewer side effects related to vasoconstriction compared to triptans in susceptible people, such as those with ischemic heart disease, Raynaud's phenomenon or after a myocardial infarction,[9] although a 1998 review has found such side-effects to rarely occur in people taking triptans.[10][11]

Adverse effects

There is a risk of driving impairment while taking lasmiditan. People are advised not to drive or operate machinery for at least eight hours after taking lasmiditan, even if they feel well enough to do so. People who cannot follow this advice are advised not to take lasmiditan. The drug causes central nervous system (CNS) depression, including dizziness and sedation. It should be used with caution if taken in combination with alcohol or other CNS depressants.[1]

History

Lasmiditan was discovered by Eli Lilly and Company and was then relicensed to CoLucid Pharmaceuticals in 2006, until CoLucid was bought by Eli Lilly in 2017, to allow Eli Lilly to reacquire the drug's intellectual property.[12] The drug is protected by patents until 2031.[13]

Phase II clinical trials for dose finding purposes were completed in 2007, for an intravenous form[14] and in early 2010, for an oral form.[15] Eli Lilly submitted a new drug application to the U.S. Food and Drug Administration (FDA) in November 2018.[16]

Three phase III clinical trials were completed. The SPARTAN trial compared placebo with 50, 100, and 200 mg of lasmiditan.[17] SAMURAI compared placebo with 100 and 200 mg doses of lasmiditan. GLADIATOR is an open-label study that compared 100 and 200 mg doses of lasmiditan in subjects that received the drug as part of a prior trial.[18]

Topline results from the SPARTAN trial showed that the drug induced met its primary and secondary endpoints in the trial. The primary result showed a statistically significant improvement in pain relief relative to placebo 2 hours after the first dose. The secondary result showed a statistically significantly greater percentage of subjects were free of their most bothersome symptom (MBS) compared with placebo at two hours following the first dose.[19]

The FDA approved lasmiditan primarily based on data from two clinical trials, Trial 1 (# NCT02439320) and Trial 2 (#NCT02605174) of 4439 subjects with migraine headaches with or without aura.[20] Trials were conducted at 224 sites in the United States, the United Kingdom, and Germany.[20]

The FDA approved the drug in October 2019.[20] It was placed into Schedule V in January 2020.[2][21]

Society and culture

Legal status

On 23 June 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Rayvow, intended for the treatment of migraine.[22] The applicant for this medicinal product is Eli Lilly Nederland B.V.[22] Rayvow was approved for medical use in the European Union in August 2022.[3][23]

Lasmiditan has not been approved for use in Canada. The drug sponsor in Canada, Eli Lilly Canada Inc., filed a New Drug Submission in February 2020 but cancelled the submission before a final decision was issued by Health Canada. Health Canada had completed their review of the submission and did not find any deficiencies in the data packages provided in the submission. However, Health Canada and Eli Lilly could not come to agreement on the interpretation of the cardiovascular data and how it would be worded in the product monograph. The drug sponsor cancelled their submission on January 26, 2021 before Health Canada issued a final decision.[24]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 "Reyvow- lasmiditan tablet". 11 October 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aea3358c-ff41-4490-9e6d-c7bf7b3de13f. 
  2. ↑ 2.0 2.1 "2020 - Placement of Lasmiditan in Schedule V". 31 January 2020. https://www.deadiversion.usdoj.gov/fed_regs/rules/2020/fr0131.htm. 
  3. ↑ 3.0 3.1 "Rayvow EPAR". 14 September 2021. https://www.ema.europa.eu/en/medicines/human/EPAR/rayvow.  Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  4. ↑ 4.0 4.1 4.2 "FDA approves new treatment for patients with migraine". U.S. Food and Drug Administration (FDA) (Press release). 11 October 2019. Archived from the original on 16 November 2019. Retrieved 17 October 2019. This article incorporates text from this source, which is in the public domain.
  5. ↑ "Lasmiditan (Professional Patient Advice)". 4 June 2019. https://www.drugs.com/ppa/lasmiditan.html. 
  6. ↑ "Lilly's Reyvow (lasmiditan) C-V, the First and Only Medicine in a New Class of Acute Treatment for Migraine (ditan), Now Available for Prescription". Eli Lilly and Company (Press release). 31 January 2020. Archived from the original on 23 February 2020. Retrieved 23 February 2020.
  7. ↑ "New Drug Therapy Approvals 2019". 31 December 2019. https://www.fda.gov/drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products/new-drug-therapy-approvals-2019. 
  8. ↑ "The ditans, a new class for acute migraine: Minireview" (in en). Journal of Current Research in Scientific Medicine 6 (1): 11. 2020. doi:10.4103/jcrsm.jcrsm_45_19. ISSN 2455-3069. http://www.jcrsmed.org/text.asp?2020/6/1/11/290252. Retrieved 26 June 2022. 
  9. ↑ "Molecule of the Month July 2010: Lasmiditan hydrochloride". Prous Science. http://www.prous.com/molecules/default.asp?ID=198. 
  10. ↑ "Cardiovascular safety of 5HT1B/1D agonists--is there a cause for concern?". Cephalalgia 18 (8): 539–545. October 1998. doi:10.1046/j.1468-2982.1998.1808539.x. PMID 9827245. 
  11. ↑ (in German) Arzneimittelwirkungen (8th ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. 2001. p. 265. ISBN 978-3-8047-1763-3. OCLC 47700647. 
  12. ↑ "Lilly buys migraine biotech CoLucid, and the drug it outlicensed, for $960M". 18 January 2017. http://www.fiercebiotech.com/biotech/lilly-buys-migraine-biotech-colucid-for-960m-and-drug-it-out-licensed. 
  13. ↑ "Lasmiditan - Eli Lilly and Company - AdisInsight". http://adisinsight.springer.com/drugs/800028519. 
  14. ↑ A Placebo-Controlled Adaptive Treatment Assignment Study of Intravenous COL-144 in the Acute Treatment of Migraine. 8 November 2019. https://clinicaltrials.gov/ct2/show/NCT00384774. Retrieved 23 February 2020. 
  15. ↑ Dose-ranging Study of Oral COL-144 in Acute Migraine Treatment. 20 December 2019. https://clinicaltrials.gov/ct2/show/NCT00883051. Retrieved 23 February 2020. 
  16. ↑ "Lilly Submits New Drug Application to the FDA for Lasmiditan for Acute Treatment of Migraine, Receives Breakthrough Therapy Designation for Emgality (galcanezumab-gnlm) for Prevention of Episodic Cluster Headache" (Press release). Eli Lilly and Company. 14 November 2018. Archived from the original on 12 October 2019. Retrieved 12 October 2019 – via PR Newswire.
  17. ↑ Clinical trial number NCT02605174 for "Three Doses of Lasmiditan (50 mg, 100 mg and 200 mg) Compared to Placebo in the Acute Treatment of Migraine (SPARTAN)" at ClinicalTrials.gov
  18. ↑ Clinical trial number NCT02565186 for "An Open-label, Long-term, Safety Study of Lasmiditan for the Acute Treatment of Migraine (GLADIATOR)" at ClinicalTrials.gov
  19. ↑ "Lilly Announces Positive Results for Second Phase 3 Study of Lasmiditan for the Acute Treatment of Migraine". https://investor.lilly.com/releasedetail.cfm?ReleaseID=1036101. 
  20. ↑ 20.0 20.1 20.2 "Drug Trials Snapshots: Reyvow". 11 October 2019. http://www.fda.gov/drugs/drug-trials-snapshots-reyvow.  This article incorporates text from this source, which is in the public domain.
  21. ↑ "Schedules of Controlled Substances: Placement of Lasmiditan in Schedule V". 31 January 2020. https://www.federalregister.gov/documents/2020/01/31/2020-01957/schedules-of-controlled-substances-placement-of-lasmiditan-in-schedule-v. 
  22. ↑ 22.0 22.1 "Rayvow: Pending EC decision". 23 June 2022. https://www.ema.europa.eu/en/medicines/human/summaries-opinion/rayvow.  Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  23. ↑ "Rayvow Product information". https://ec.europa.eu/health/documents/community-register/html/h1587.htm. 
  24. ↑ "Regulatory Decision Summary - Reyvow". Health Canada. 23 October 2014. https://hpr-rps.hres.ca/reg-content/regulatory-decision-summary-detailTwo.php?lang=en&linkID=RDS00789. 

External links



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