Chemistry:2-Phenyl-1-benzothiophene

From HandWiki

2-Phenyl-1-benzothiophene is an aromatic chemical compound commonly used as an intermediate in the production of medication. Derivatives of the compound are present in drugs used to treat Alzheimer's disease, and its structure is present in the selective estrogen receptor modulator drugs raloxifene and arzoxifene.[1] Its formula is C
14H
10S.

2-Phenyl-1-benzothiophene is an intermediate in pesticide synthesis, in addition to its uses in the pharmaceutical field. Typically, it is produced through three methods: an arylation reaction of benzothiophene; a coupling reaction between 2-benzothiophene boronic acid and a benzene-donating compound; or cyclization of aromatic molecules.[2]

References

  1. ↑ Zhong, Yu-Jie; Zhao, Ke-Qing; Wang, Bi-Qin; Hu, Ping; Monobe, Hirosato; Heinrich, Benoît; Donnio, Bertrand (2020). "2-Phenylbenzothiophene-based liquid crystalline semiconductors" (in en). Dyes and Pigments 173. doi:10.1016/j.dyepig.2019.107964. https://hal.archives-ouvertes.fr/hal-03007425/file/Dyes%26Pigments2020_107964.pdf. 
  2. ↑ Duan, Zhongyu; Gao, Yujuan (2013-06-01). "Recent Progress in the Synthesis of 2-Phenyl-benzo[bthiophene"] (in en). Chinese Journal of Applied Chemistry 30 (6): 611. doi:10.3724/SP.J.1095.2013.20394. ISSN 1000-0518. https://engine.scichina.com/doi/10.3724/SP.J.1095.2013.20394. 




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