Chemistry:Estriol dipropionate
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Short description: Chemical compound
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| Other names | Oestriol dipropionate; Estriol 3,17β-dipropionate; 16α-Hydroxyestra-1,3,5(10)-triene-3,17β-diyl dipropanoate |
| Routes of administration | Intramuscular injection |
| Drug class | Estrogen; Estrogen ester |
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| Formula | C24H32O5 |
| Molar mass | 400.515 g·mol−1 |
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Estriol dipropionate, or estriol 3,17β-dipropionate, is a synthetic estrogen and estrogen ester – specifically, the C3 and C17β dipropionate ester of estriol – which was first described in 1963 and was never marketed.[1][2][3] Following a single intramuscular injection of 6.94 mg estriol dipropionate (equivalent to 5.0 mg estriol) in an oil solution, peak levels of estriol occurred after 0.83 days, an elimination half-life of 12.7 hours was observed, and estriol levels remained elevated for up to 4 days.[1][3] For comparison, the duration of estriol was much shorter, while that of estriol dihexanoate was much longer.[1][3]
See also
References
- ↑ 1.0 1.1 1.2 "Pharmacokinetics and Exogenous Natural and Synthetic Estrogens and Antiestrogens". Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. 6 December 2012. pp. 273–. ISBN 978-3-642-60107-1. https://books.google.com/books?id=wBvyCAAAQBAJ&pg=PA273.
- ↑ "Preparation of some estriol esters". Chemical & Pharmaceutical Bulletin 11 (4): 510–514. April 1963. doi:10.1248/cpb.11.510. PMID 13994597.
- ↑ 3.0 3.1 3.2 "Plasma estriol levels after intramuscular injection of estriol and two of its esters". Hormone Research 35 (6): 234–238. 1991. doi:10.1159/000181911. PMID 1819548.
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