Chemistry:2-MAPB

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Short description: Chemical compound
2-MAPB
2MAPB structure.png
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC12H15NO
Molar mass189.258 g·mol−1
3D model (JSmol)

2-MAPB is a recreational designer drug with empathogenic effects. As with other related substituted benzofuran derivatives such as 6-APB and 5-MAPB, 2-MAPB is a monoamine releaser with some selectivity for serotonin release, generally similar in pharmacological profile to MDMA but with greater activity as a directly acting agonist of 5-HT2 receptor subtypes and somewhat greater toxicity.[1] 2-MAPB has been isolated from post-mortem toxicology screens in several drug-related fatal adverse reactions but generally only as a component of combinations of drugs, making it difficult to determine how much it contributed to the deaths.[2][3] It is illegal in Japan .[4]

See also

References

  1. "Novel psychoactive benzofurans strongly increase extracellular serotonin level in mouse corpus striatum". The Journal of Toxicological Sciences 41 (3): 329–337. 2016. doi:10.2131/jts.41.329. PMID 27193726. 
  2. "Postmortem distribution and redistribution of MDAI and 2-MAPB in blood and alternative matrices". Forensic Science International 279: 83–87. October 2017. doi:10.1016/j.forsciint.2017.08.007. PMID 28850871. https://www.zora.uzh.ch/id/eprint/141467/2/doi.org10.1016j.forsciint.2017.08.007.pdf. 
  3. "Toxicological investigations in a death involving 2-MAPB". Forensic Science, Medicine, and Pathology 17 (2): 317–321. June 2021. doi:10.1007/s12024-021-00366-0. ISSN 1547-769X. PMID 33877515. 
  4. "指定薬物名称・構造式一覧(平成27年9月16日現在)" (in ja). 厚生労働省. 16 September 2015. http://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/dl/meisho.pdf.