Chemistry:ALA-10

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ALA-10, also known as 1-acetyl-LAE (1A-LAE), is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2][3] It is the 1-acetyl derivative of LAE-32.[2][3][4][5] 1-Acetylated lysergamides like ALD-52 (1-acetyl-LSD; 1A-LSD) are thought to function as prodrugs via deacetylation to the 1-unsubstituted analogues, which in the case of ALD-52 is LSD.[6][7][8]

Use and effects

ALA-10 is active at a dose of approximately 1.2 mg orally in humans and has around 7 to 10% of the potency of LSD.[1][2][3][9][10] It produces LSD-like psychic effects.[2][10] It is said to have a quicker onset and shorter duration than LSD.[2][10] For comparison, LAE-32, has a dose range of 0.5 to 1.6 mg, about 5 to 10% of the activity of LSD, and a likewise faster onset and shorter duration than LSD.[1][2][3][9] Both ALA-10 and LAE-32 are said to produce only slight or weak hallucinogenic effects.[11] ALA-10 is around 15-fold less potent than ALD-52 (1-acetyl-LSD), which is roughly equipotent with LSD.[1][2][3]

Interactions

Pharmacology

Pharmacodynamics

ALA-10 shows antiserotonergic activity in the isolated rat uterus of about 39% of that of LSD but about 3 times stronger than that of LAE-32.[1][10] Its pyretogenic potency in rabbits is only about 1% of that of LSD.[1]

History

ALA-10 was first described in the scientific literature by the late 1950s.[1][10]

See also

  • Substituted lysergamide
  • MLA-74 (1-methyl-LAE)
  • ALD-52 (1-acetyl-LSD; 1A-LSD)

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "Some Compounds With Hallucinogenic Activity". Ergot Alkaloids and Related Compounds. Handbook of Experimental Pharmacology (HEP). 49. Berlin, Heidelberg: Springer Berlin Heidelberg. 1978. pp. 567–614. doi:10.1007/978-3-642-66775-6_8. ISBN 978-3-642-66777-0. https://bibliography.maps.org/resources/download/8769#page=30. "I-Acetyl-lysergic acid ethylamide (ALA 10, No. 36g), the acetylated analogue of LAE 32, exhibits 7% of the psychotomimetic effect of LSD (ISBELL et a!., 1959a). Its antiserotonin potency on the isolated rat uterus is 40% of that of LSD (thus three times stronger than LAE 32), whereas its pyretogenic effect in rabbits is only 1 % of the LSD action (Sandoz Res. Lab., 1958). [...] Also if applied to the less potent lysergic acid ethylamide or pyrrolidide, the 1-substitution (ALA 10, MLA 74, MPD75) only slightly affects the psychotomimetic activity of the parent compounds LAE 32 and LPD 824. [...] Table 2. Psychotomimetic activity and some pharmacodynamic effects of structural analogues of LSD [...] The monosubstituted ethyl-analogues LAE32, ALA 10, MLA 74 are psychotomimetic, but about 10-20 times weaker than the corresponding diethylamides LSD, ALD 52, and MLD41. [...]" 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Indolealkylamines and Related Compounds". Hallucinogenic Agents. Bristol: Wright-Scientechnica. 1975. pp. 98–144. ISBN 978-0-85608-011-1. OCLC 2176880. https://bitnest.netfirms.com/external/Books/978-0-85608-011-1#page=55. "Table 4.3.—Comparative Hallucinogenic Potencies in Man of Derivatives of D-Lysergic Acid. [...]" 
  3. ↑ 3.0 3.1 3.2 3.3 3.4 "Basic Pharmacology and Effects". Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. 2003. pp. 67–137. ISBN 978-0-12-433951-4. https://web.archive.org/web/20250223164514/https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=6bb3a7499da8e9852b39cd4db16891147c83f5c6. 
  4. ↑ "#26. LSD-25 Acid; Lysergide; D-Lysergic Acid Diethylamide; Meth-LAD; D-Lysergamide, N,N-Diethyl; N,N-Diethyl-D-Lysergamide; 9,10-Didehydro-N,N-Diethyl-6-Methylergoline-8b-Carboxamide". TiHKAL: The Continuation (1st ed.). Berkeley, CA: Transform Press. 1997. pp. 490–499. ISBN 978-0-9630096-9-2. OCLC 38503252. https://www.erowid.org/library/books_online/tihkal/tihkal26.shtml. 
  5. ↑ "Chemical Background". Ergot Alkaloids and Related Compounds. Handbook of Experimental Pharmacology (HEP). 49. Berlin, Heidelberg: Springer Berlin Heidelberg. 1978. pp. 29–85. doi:10.1007/978-3-642-66775-6_2. ISBN 978-3-642-66777-0. 
  6. ↑ "Prodrugs of New Psychoactive Substances (NPS): A New Challenge". Journal of Forensic Sciences 65 (3): 913–920. May 2020. doi:10.1111/1556-4029.14268. PMID 31943218. "Recently, a number of LSD derivatives and analogues have been investigated, namely 1-acetyl-LSD (1A-LSD, ALD-52), [...] (46-52) (Figure 1B). A biotransformation has been observed in lysergamides acylated at the indole nitrogen that in turn produce the corresponding “core” drug of LSD or ETH-LAD (52). Therefore, 1P-LSD, 1B-LSD and ALD-52 are all prodrugs of LSD and 1P-ETH-LAD is a prodrug of ETH-LAD. All of these drugs have been discussed in Internet drug forums and are currently available for purchase online (53-56). Although ALD-52 was known to be psychoactive in humans for a long time (57), the formation of LSD both in vitro and in vivo (rats) has only been confirmed recently (51,57).". 
  7. ↑ "The use of prodrugs as drugs of abuse". WIREs Forensic Science 6 (3). 2024. doi:10.1002/wfs2.1514. ISSN 2573-9468. 
  8. ↑ "Stimulant and hallucinogenic novel psychoactive substances; an update". Expert Review of Clinical Pharmacology 16 (11): 1109–1123. 2023. doi:10.1080/17512433.2023.2279192. PMID 37968919. 
  9. ↑ 9.0 9.1 "Structure-activity relationships of the classic hallucinogens and their analogs". NIDA Research Monograph 146: 74–91. 1994. PMID 8742795. 
  10. ↑ 10.0 10.1 10.2 10.3 10.4 "Relationships of psychotomimetic to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25)". Psychopharmacologia 1: 20–28. 1959. doi:10.1007/BF00408108. PMID 14405872. https://bibliography.maps.org/resources/download/13773#page=4. 
  11. ↑ "Structure-Activity Relationship among Hallucinogenic Agents". Origin and Mechanisms of Hallucinations. Boston, MA: Springer US. 1970. pp. 345–376. doi:10.1007/978-1-4615-8645-6_29. ISBN 978-1-4615-8647-0. http://link.springer.com/10.1007/978-1-4615-8645-6_29. Retrieved 12 October 2025. "A relation in the same direction might exist between the two N-monoethyl analogues ALA-10 and MLA-74, if judged by their LD50; both are only slightly psychotomimetic. The unsubstituted N-monoethyl analogue of LSD itself is a weak hallucinogen only [122]." 

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