Chemistry:AWD 52-39

From HandWiki

AWD 52-39
Clinical data
Other namesN,N-Diacetoxyethyl-9,10-dihydrolysergamide
Drug classNootropic; Serotonin receptor modulator
ATC code
  • None
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC24H31N3O5
Molar mass441.528 g·mol−1
3D model (JSmol)

AWD 52-39, also known as N,N-diacetoxyethyl-9,10-dihydrolysergamide, is a drug described as a "nootropic" (cognitive enhancer) of the lysergamide family related to lysergic acid diethylamide (LSD) that was never marketed.[1][2][3] It was under development by Arzneimittelwerk Dresden, but development was discontinued.[2] The effects of AWD 52-39 in preclinical studies have been reported.[3][4][5][6] The drug has been found to enhance learning and memory and to produce antidepressant-like effects in rodents.[1] It appears to act upon vascular serotonin receptors.[5] The chemical synthesis and stereochemistry of AWD 52-39 have been described.[7] The drug was first described in the scientific literature by 1989.[3]

See also

References

  1. ↑ 1.0 1.1 "Effects of the novel compound AWD 52-39 on behavioral test methods for evaluation of memory-enhancing drugs". European Journal of Pharmacology 183 (4): 1480. 1990. doi:10.1016/0014-2999(90)94625-8. https://linkinghub.elsevier.com/retrieve/pii/0014299990946258. Retrieved 15 October 2025. 
  2. ↑ 2.0 2.1 "Cognitive enhancers (nootropics). Part 3: drugs interacting with targets other than receptors or enzymes. disease-modifying drugs". Journal of Alzheimer's Disease 34 (1): 1–114. 2013. doi:10.3233/JAD-121729. PMID 23186990. http://infoscience.epfl.ch/record/185511. 
  3. ↑ 3.0 3.1 3.2 "AWD 52-39, an ergot derivative with potential nootropic activity". Activitas Nervosa Superior 31 (1): 56–57. April 1989. PMID 2782003. 
  4. ↑ "Effects of the nootropic AWD 52-39 on the blood-brain transfer of leucine, choline and glucose in rats after 14-d exposure to ethanol". Die Pharmazie 47 (8): 616–620. August 1992. PMID 1438514. 
  5. ↑ 5.0 5.1 "Effect of AWD 52-39 on vasoconstriction induced by noradrenaline and 5-hydroxytryptamine in vitro and in vivo in rats". Die Pharmazie 47 (2): 137–139. February 1992. PMID 1635923. 
  6. ↑ "Blood-brain barrier transport under different physiological and pathophysiological circumstances including ischemia". Experimental Pathology 42 (4): 213–219. 1991. doi:10.1016/s0232-1513(11)80068-x. PMID 1959581. 
  7. ↑ "Synthese und Stereochemie von AWD 52-39." (in de). Pharmazie 50 (5): 351–354. 1995. https://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3502653. 



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