Chemistry:1cP-LSD

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1cP-LSD, or 1-CPA-LSD, also known as 1-cyclopropanoyl-LSD or as Curie, is a psychedelic drug of the lysergamide family and an acylated derivative of lysergic acid diethylamide (LSD) which has been sold as a designer drug.[1][2][3][4] It is a prodrug of LSD.[1]

Use and effects

1cP-LSD has been used in the form of blotter tabs containing 100 μg 1cP-LSD free base and pellets containing 150 μg 1cP-LSD hemitartrate.[1] Its dose is said to be 100 to 200 μg and it has comparable potency to 1P-LSD and 1B-LSD.[4][5] Its duration has been said to be 5 to 10 hours.[4][5]

Interactions

Pharmacology

Pharmacodynamics

1cP-LSD is a prodrug of LSD.[1] It has been found to produce psychedelic-like effects, specifically the head-twitch response, in rodents with similar potency as 1P-LSD.[1]

Chemistry

Analogues

Related compounds include 1B-LSD, 1DD-LSD, 1P-LSD, 1V-LSD, ALD-52 (1A-LSD), 1cP-AL-LAD, AL-LAD, ETH-LAD, 1P-ETH-LAD, PRO-LAD, LSM-775, and LSZ, among others.

History

Society and culture

1cP-LSD on blotter paper.

Canada

1cP-LSD is not a controlled substance in Canada as of 2025.[6]

Sweden

Sweden's public health agency suggested classifying 1cP-LSD as a dangerous substance on 18 December 2019 and later classified it as such on 22 April 2021.[7][8]

United States

1cP-LSD is not an explicitly controlled substance in the United States.[9] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

Research

1cP-LSD has been investigated as a potential treatment for anxiety in dogs and cats.[10][11]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 "Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD)". Drug Testing and Analysis 12 (6): 812–826. June 2020. doi:10.1002/dta.2789. PMID 32180350. 
  2. ↑ "[Identification of LSD Derivatives, 1cP-LSD, MIPLA and 1B-LSD in Illegal Products as Paper Sheet]". Yakugaku Zasshi 140 (11): 1405–1413. 2020. doi:10.1248/yakushi.20-00124. PMID 33132277. 
  3. ↑ "Seizures of New Psychoactive Substances on the Italian territory during the COVID-19 pandemic". Forensic Science International 326. September 2021. doi:10.1016/j.forsciint.2021.110904. PMID 34371393. 
  4. ↑ 4.0 4.1 4.2 "1cP-LSD" (in ru). https://aipsin.com/newsubstance/250/. 
  5. ↑ 5.0 5.1 "1cP-LSD" (in ru). https://aipsin.com/newsubstance/324/. 
  6. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  7. ↑ "Förordning (1999:58) om förbud mot vissa hälsofarliga varor". https://www.riksdagen.se/sv/dokument-lagar/dokument/svensk-forfattningssamling/forordning-199958-om-forbud-mot-vissa_sfs-1999-58/. 
  8. ↑ "Tjugotre ämnen föreslås klassas som narkotika eller hälsofarlig vara" (in sv). Folkhälsomyndigheten. December 18, 2019. https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/december/tjugotre-amnen-foreslas-klassas-som-narkotika-eller-halsofarlig-vara/. 
  9. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf 
  10. ↑ "Evaluating the Potential of Microdosing 1cp-LSD for the Treatment of Canine Anxiety: A One-Month Case Study". Veterinary Medicine and Science 11 (4). July 2025. doi:10.1002/vms3.70486. PMID 40638522. 
  11. ↑ "Preliminary Findings on Low-Dose 1cp-LSD for Canine Anxiety: Exploring the Role of Owner Neuroticism and Psychopathology". Veterinary Sciences 12 (9): 872. September 2025. doi:10.3390/vetsci12090872. PMID 41012797. 



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