Chemistry:1cP-LSD

1cP-LSD
Clinical data
Routes of; administration	By mouth, under the tongue
Legal status
Legal status	AU: Unscheduled. ; BR: F2 ; CA: Unscheduled. ; DE: NpSG (Industrial and scientific use only) ; UK: Under Psychoactive Substances Act ; US: Unscheduled Could be illegal if is sold for recreational use or for human consumption.;
Identifiers
	IUPAC name (6aR,9R)-N,N-diethyl-7-methyl-4-cyclopropylmethanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide;
PubChem CID	155884675;
ChemSpider	107450612;
UNII	7UU7S6TN3J;
Chemical and physical data
Formula	C24H29N3O2
Molar mass	391.515 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)C1CC1)c4cccc2c34)N(C)C5;
	InChI InChI=1S/C24H29N3O2/c1-4-26(5-2)23(28)17-11-19-18-7-6-8-20-22(18)16(12-21(19)25(3)13-17)14-27(20)24(29)15-9-10-15/h6-8,11,14-15,17,21H,4-5,9-10,12-13H2,1-3H3/t17-,21-/m1/s1; Key:RAFUPYYDHPFASC-DYESRHJHSA-N;

Short description: Chemical compound

1cP-LSD (N1-(cyclopropylmethanoyl)-lysergic acid diethylamide) is an acylated derivative of lysergic acid diethylamide (LSD), which has been sold as a designer drug. ^[1]^[2] In tests on mice it was found to be an active psychedelic with similar potency to 1P-LSD.^[3]

Legal status

Sweden's public health agency suggested classifying 1cP-LSD as a dangerous substance on 18 December 2019 and later classified it as such on 22 April 2021.^[4]^[5]

References

↑ "[Identification of LSD Derivatives, 1cP-LSD, MIPLA and 1B-LSD in Illegal Products as Paper Sheet]". Yakugaku Zasshi 140 (11): 1405–1413. 2020. doi:10.1248/yakushi.20-00124. PMID 33132277.
↑ "Seizures of New Psychoactive Substances on the Italian territory during the COVID-19 pandemic". Forensic Science International 326: 110904. July 2021. doi:10.1016/j.forsciint.2021.110904. PMID 34371393.
↑ "Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD)". Drug Testing and Analysis 12 (6): 812–826. June 2020. doi:10.1002/dta.2789. PMID 32180350.
↑ "Förordning (1999:58) om förbud mot vissa hälsofarliga varor". https://www.riksdagen.se/sv/dokument-lagar/dokument/svensk-forfattningssamling/forordning-199958-om-forbud-mot-vissa_sfs-1999-58/.
↑ "Tjugotre ämnen föreslås klassas som narkotika eller hälsofarlig vara" (in sv). Folkhälsomyndigheten. December 18, 2019. https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/december/tjugotre-amnen-foreslas-klassas-som-narkotika-eller-halsofarlig-vara/.

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[1] "[Identification of LSD Derivatives, 1cP-LSD, MIPLA and 1B-LSD in Illegal Products as Paper Sheet]". Yakugaku Zasshi 140 (11): 1405–1413. 2020. doi:10.1248/yakushi.20-00124. PMID 33132277.

[pmid34371393-2] "Seizures of New Psychoactive Substances on the Italian territory during the COVID-19 pandemic". Forensic Science International 326: 110904. July 2021. doi:10.1016/j.forsciint.2021.110904. PMID 34371393.

[3] "Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD)". Drug Testing and Analysis 12 (6): 812–826. June 2020. doi:10.1002/dta.2789. PMID 32180350.

[4] "Förordning (1999:58) om förbud mot vissa hälsofarliga varor". https://www.riksdagen.se/sv/dokument-lagar/dokument/svensk-forfattningssamling/forordning-199958-om-forbud-mot-vissa_sfs-1999-58/.

[5] "Tjugotre ämnen föreslås klassas som narkotika eller hälsofarlig vara" (in sv). Folkhälsomyndigheten. December 18, 2019. https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2019/december/tjugotre-amnen-foreslas-klassas-som-narkotika-eller-halsofarlig-vara/.

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v t e Ergolines
Lysergic acid derivatives	2-Bromo-LSD (BOL-148) Bromocriptine Cabergoline Dihydroergocornine Dihydroergocristine Dihydroergocryptine Dihydroergometrine (Dihydroergonovine, Dihydroergobasine) Dihydroergosine Dihydroergotamine Epicriptine Ergine (LSA; LA-111; Lysergamide) Ergocornine Ergocristine Ergocryptine Ergoloid (Dihydroergotoxine) Ergometrine (Ergonovine, Ergobasine) Ergometrinine Ergotamine Ergotoxine Ergovaline Lisuride LSD LSH Lysergic Acid Lysergic acid cyclobutylamide Lysergic acid cyclopentylamide Lysergic Acid Methyl Ester Lysergol Mesulergine Metergoline Methergine (Methylergometrine, Methylergonovine, Methylergobasine) Methysergide Pergolide Syntometrine
Psychedelic lysergamides	1B-LSD 1P-ETH-LAD 1P-LSD AL-LAD ALD-52 BU-LAD CYP-LAD DAL DAM-57 ECPLA Ergonovine ETFELA ETH-LAD IP-LAD LAMPA LAE-32 LSD LPD-824 LSM-775 LSH LSD-Pip Lysergic Acid 2-Butylamide Lysergic Acid 2,4-Dimethylazetidide Lysergic Acid 3-Pentylamide Methylergonovine MIPLA MLD-41 PARGY-LAD PRO-LAD
clavines	agroclavine elymoclavine lysergol festuclavine fumigaclavine A fumigaclavine B fumigaclavine C
Other ergolines	Ergoline
Natural sources	Achnatherum robustum (Sleepy Grass) Claviceps spp. (Ergot) Morning glory: Argyreia nervosa (Hawaiian Baby Woodrose), Ipomoea spp.(Morning Glory, Tlitliltzin, Badoh Negro), Rivea corymbosa (Coaxihuitl, Ololiúqui)

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Clinical data

Routes of administration	By mouth, under the tongue
Legal status
Legal status	AU: Unscheduled. BR: F2 CA: Unscheduled. DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act US: Unscheduled Could be illegal if is sold for recreational use or for human consumption.
Identifiers
IUPAC name (6aR,9R)-N,N-diethyl-7-methyl-4-cyclopropylmethanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
PubChem CID	155884675
ChemSpider	107450612
UNII	7UU7S6TN3J
Chemical and physical data
Formula	C₂₄H₂₉N₃O₂
Molar mass	391.515 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)C1CC1)c4cccc2c34)N(C)C5
InChI InChI=1S/C24H29N3O2/c1-4-26(5-2)23(28)17-11-19-18-7-6-8-20-22(18)16(12-21(19)25(3)13-17)14-27(20)24(29)15-9-10-15/h6-8,11,14-15,17,21H,4-5,9-10,12-13H2,1-3H3/t17-,21-/m1/s1 Key:RAFUPYYDHPFASC-DYESRHJHSA-N

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