Chemistry:1F-LSD

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1F-LSD, also known as 1-(furan-2-carbonyl)-LSD, 1-(2-furoyl)-LSD, or SYN-L-005, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2] It is thought to act as a prodrug of LSD.[1][2] The drug interacts with serotonin receptors, including the serotonin 5-HT2A receptor, and produces the head-twitch response in rodents, with about 3-fold lower potency than LSD.[1] It hydrolyzes into LSD in rodents.[1] 1F-LSD was patented in 2024[2] and was first described in the scientific literature in 2025.[1] It has been encountered as a novel designer drug in Germany and Japan.[1]

Interactions

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References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD)". Drug Test Anal 17 (8): 1283–1293. August 2025. doi:10.1002/dta.3829. PMID 39624022. 
  2. ↑ 2.0 2.1 2.2 Stratford A, Williamson JP, "Prodrugs of Substituted Ergolines", WO patent 2024/028495, published 8 February 2024

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