Chemistry:6-MeO-RU-28306

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6-MeO-RU-28306, or 6-methoxy-RU-28306, also known as 4,α-methylene-5-methoxy-N,N-dimethyltryptamine (4,α-methylene-5-MeO-DMT), is a serotonin receptor modulator and a cyclized tryptamine and partial ergoline.[1] It is the 6-methoxy derivative of RU-28306 (4,α-methylene-DMT) and a cyclized derivative of 5-MeO-DMT.[1] The drug showed affinity for the serotonin-labeled serotonin 5-HT1 receptors and spiperone-labeled serotonin 5-HT2 receptors in rat frontal cortex membranes in vitro (IC50 = 96 nM and 1,756 nM, respectively).[1] 6-MeO-RU-28306 robustly reduced hypothalamic 5-hydroxyindoleacetic acid (5-HIAA) levels and increased circulating corticosterone levels in rodents in vivo, which are both measures of serotonin receptor agonist activity.[1] The chemical synthesis of 6-MeO-RU-28306 has been described.[1] 6-MeO-RU-28306 was first described in the scientific literature by 1988.[1]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "6-substituted 1,3,4,5-tetrahydrobenz[cd]indol-4-amines: potent serotonin agonists". Journal of Medicinal Chemistry 31 (9): 1746–1753. September 1988. doi:10.1021/jm00117a013. PMID 2457705. 



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