Chemistry:FP-LAD

From HandWiki

FP-LAD, also known as fluoro-PRO-LAD or as TRALA-16, is a serotonin receptor modulator of the lysergamide family related to lysergic acid diethylamide (LSD; METH-LAD).[1] It is specifically a fluorinated derivative of PRO-LAD (6-propyl-6-nor-LSD) and an analogue of FLUORETH-LAD (FE-LAD; 6-ethyl-6-nor-LSD).[1]

The drug has been reported to act as a potent ligand of the serotonin 5-HT2 receptors.[1] It had affinities (Ki) of 0.93 nM at the serotonin 5-HT2A receptor, 1.8 nM at the serotonin 5-HT2B receptor, and 3.7 nM at the serotonin 5-HT2C receptor.[1] FP-LAD was assessed and found to be a full agonist of the serotonin 5-HT2A and 5-HT2C receptors, with EC50 and Emax values of 0.48 nM (93%) and 1.7 nM (97%), respectively.[1] It had several-fold greater activational potency than LSD at the serotonin 5-HT2A and 5-HT2C receptors.[1]

The chemical synthesis of FP-LAD has been described.[1]

FP-LAD was patented by Daniel Trachsel and Matthias Liechti and colleagues in association with MindMed (Mind Medicine) in 2023.[1] It had also previously been described in an earlier patent by Andrew Kruegel in association with Gilgamesh Pharmaceuticals in 2022.[2] Hamilton Morris has described synthesizing FP-LAD and/or 1P-FP-LAD with Lizard Labs in 2025.[3][4]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Trachsel D, Liechti ME, Lustenberger F, "Lysergic acid derivatives with modified LSD-like action", US patent 2023/0414583, published 28 December 2023
  2. ↑ Kruegel AC, "Novel ergolines and methods of treating mood disorders", WO patent 2022226408A1, published 25 April 2022 Example 13: Preparation of (6aR,9R)-N,N-diethyl-7-(cyclopropylmethyl)-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (13) [...]
  3. ↑ Andrew Callaghan (27 September 2025). "The Fight for Legal Psychedelics (#12)". Channel 5 with Andrew Callaghan (Podcast). YouTube. Event occurs at 1:14:26–1:15:32. [...] I just made a really interesting variant of LSD. I don't know if I have to bleep this out, but it was propyl-fluoro-1-propionyl-nor-LSD. And 6-propylfluoro. [...]
  4. ↑ Adam Jay Moskowitz (2 October 2025). "Drug Journalist Hamilton Morris on Why All Drugs Should Be Legal". A Cheese Course (Podcast). YouTube. Event occurs at 29:48–31:12. [...]



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