Chemistry:Levonorgestrel cyclopropylcarboxylate

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Short description: Chemical compound
Levonorgestrel cyclopropylcarboxylate
Levonorgestrel cyclopropylcarboxylate.svg
Clinical data
Other namesHRP-003; HRP003; Levonorgestrel cyclopropyl-carboxylate; Levonorgestrel 17β-cyclopropylcarboxylate; 17α-Ethynyl-18-methyl-19-nortestosterone 17β-cyclopropylcarboxylate; 17α-Ethynyl-18-methylestr-4-en-17β-ol-3-one 17β-cyclopropylcarboxylate; 13-Ethyl-17α-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one cyclopropanecarboxylate
Routes of
administration		Intramuscular injection
Drug classProgestogen; Progestin; Progestogen ester
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC25H32O3
Molar mass380.528 g·mol−1
3D model (JSmol)

Levonorgestrel cyclopropylcarboxylate (developmental code name HRP-003), or levonorgestrel 17β-cyclopropylcarboxylate, is a progestin and a progestogen ester which was studied for potential use as an injectable hormonal contraceptive but was never marketed.[1][2][3][4][5][6][7][8][9][10] It was developed by the World Health Organization's Special Programme on Human Reproduction in the 1980s.[1][2][9] Analogues of levonorgestrel cyclopropylcarboxylate include levonorgestrel cyclobutylcarboxylate (HRP-001) and levonorgestrel butanoate (HRP-002).[1][2][3]

See also

References

  1. ↑ 1.0 1.1 1.2 Benagiano, G., & Merialdi, M. (2011). Carl Djerassi and the World Health Organisation special programme of research in human reproduction. Journal für Reproduktionsmedizin und Endokrinologie-Journal of Reproductive Medicine and Endocrinology, 8(1), 10-13. http://www.kup.at/kup/pdf/10163.pdf
  2. ↑ 2.0 2.1 2.2 "Long-acting hormonal contraceptives for women". The Journal of Steroid Biochemistry and Molecular Biology 40 (4–6): 697–704. 1991. doi:10.1016/0960-0760(91)90293-E. PMID 1958567. 
  3. ↑ 3.0 3.1 "Long-acting injectable hormonal dosage forms for contraception". Pharmaceutical Research 32 (7): 2180–2191. July 2015. doi:10.1007/s11095-015-1686-2. PMID 25899076. 
  4. ↑ "Trends in Hormonal Contraception". Female Contraception. 1988. pp. 109–121. doi:10.1007/978-3-642-73790-9_9. ISBN 978-3-642-73792-3. 
  5. ↑ Contraception: Science and Practice. Elsevier Science. 22 October 2013. pp. 112–. ISBN 978-1-4831-6366-6. https://books.google.com/books?id=Ug3-BAAAQBAJ&pg=PA112. 
  6. ↑ The Contraception Sourcebook. McGraw Hill Professional. 4 December 2001. p. 133. ISBN 978-0-07-139945-6. https://books.google.com/books?id=HWoWwGwlEcUC. 
  7. ↑ Long-Acting Contraceptive Delivery Systems: Proceedings of an International Workshop on Long-Acting Contraceptive Delivery Systems, May 31-June 3, 1983, New Orleans, Louisiana. Harper & Row Pub.. 1984. p. 196. ISBN 978-0-06-142905-7. https://books.google.com/books?id=QKtsAAAAMAAJ. 
  8. ↑ Fertility regulation today and tomorrow. Raven Press. 1987. p. 132. ISBN 978-0-88167-180-3. https://books.google.com/books?id=-GJqAAAAMAAJ. 
  9. ↑ 9.0 9.1 Recent advances in fertility control: proceedings of the 1st International Symposium on Recent Advances in Fertility Control, Tokyo, November 8, 1986. Excerpta Medica. 1987. p. 67. ISBN 978-90-219-1638-5. https://books.google.com/books?id=X6tsAAAAMAAJ. 
  10. ↑ Contraception: newer pharmacological agents, devices, and delivery systems. M. Dekker. 1992. p. 62. ISBN 978-0-8247-8700-4. https://books.google.com/books?id=L5NsAAAAMAAJ. 



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