Chemistry:Metfendrazine

Metfendrazine
Clinical data
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 1-methyl-1-(1-methyl-2-phenyl-ethyl)hydrazine;
CAS Number	3734-26-7 ;
PubChem CID	19516;
ChemSpider	18390;
UNII	A52QTC656T;
Chemical and physical data
Formula	C10H16N2
Molar mass	164.252 g·mol−1

Short description: Chemical compound

Metfendrazine (HM-11, MO-482), also known as methphendrazine, is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class.^[1]^[2] It was investigated as an antidepressant, but was never marketed.

References

↑ "Metfendrazine, a new inhibitor of monoamine oxidase". Archivos del Instituto de Farmacología Experimental (Madrid) 14: 47–59. 1962.
↑ "A comparison of perphenazine, proketazine, nialamide and MO-482 in chronic schizophrenics". The American Journal of Psychiatry 117 (4): 358–360. October 1960. doi:10.1176/ajp.117.4.358. PMID 13753478.

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v t e Anxiolytics (N05B)
5-HT_1AR agonists	Buspirone Gepirone^† Tandospirone
GABA_AR PAMs	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem^‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Chlormezanone^‡ Ethanol (alcohol) Etifoxine Imepitoin; Herbs: Kava Skullcap Valerian
Gabapentinoids (α₂δ VDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIs (e.g., escitalopram) SNRIs (e.g., duloxetine) SARIs (e.g., trazodone) TCAs (e.g., clomipramine^#) TeCAs (e.g., mirtazapine) MAOIs (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol)
Others	Benzoctamine Cannabidiol Cycloserine Fabomotizole Hydroxyzine Kanna Lavender Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Clinical data

Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 1-methyl-1-(1-methyl-2-phenyl-ethyl)hydrazine
CAS Number	3734-26-7^Y
PubChem CID	19516
ChemSpider	18390
UNII	A52QTC656T
Chemical and physical data
Formula	C₁₀H₁₆N₂
Molar mass	164.252 g·mol⁻¹