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Short description
ICI-190,622 Clinical data ATC code Identifiers
4-Amino-1-pent-3-ynyl-N -prop-2-enylpyrazolo[3,4-b]pyridine-5-carboxamide
CAS Number PubChem CID ChemSpider UNII ChEMBL Chemical and physical data Formula C 15 H 17 N 5 O Molar mass −1 3D model (JSmol )
CC#CCCN1C2=NC=C(C(=C2C=N1)N)C(=O)NCC=C
InChI=1S/C15H17N5O/c1-3-5-6-8-20-14-11(10-19-20)13(16)12(9-18-14)15(21)17-7-4-2/h4,9-10H,2,6-8H2,1H3,(H2,16,18)(H,17,21)
N Key:ZPOHUNITDKKDQD-UHFFFAOYSA-N
N N Y (what is this?) (verify)
ICI-190,622 is an anxiolytic drug used in scientific research. It is a pyrazolopyridine derivative, related to other anxiolytic compounds such as tracazolate , and more distantly to zaleplon . It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1] [2]
See also References
↑ "Preclinical studies with pyrazolopyridine non-benzodiazepine anxiolytics: ICI 190,622". Pharmacology Biochemistry and Behavior 29 (4): 775–9. April 1988. doi :10.1016/0091-3057(88)90205-5 . PMID 2901116 . ↑ "Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents". Journal of Medicinal Chemistry 32 (12): 2561–73. December 1989. doi :10.1021/jm00132a011 . PMID 2573731 .
Alcohols Barbiturates Benzodiazepines Carbamates Flavonoids Imidazoles Kava constituentsMonoureides Neuroactive steroids Nonbenzodiazepines Phenols Piperidinediones Pyrazolopyridines Quinazolinones Volatiles /gases Others/unsorted
3-Hydroxybutanal α-EMTBL AA-29504 Avermectins (e.g., ivermectin )Bromide compounds (e.g., lithium bromide , potassium bromide , sodium bromide) Carbamazepine Chloralose Chlormezanone Clomethiazole DEABL Dihydroergolines (e.g., dihydroergocryptine , dihydroergosine , dihydroergotamine , ergoloid (dihydroergotoxine) )DS2 Efavirenz Etazepine Etifoxine Fenamates (e.g., flufenamic acid , mefenamic acid , niflumic acid , tolfenamic acid )Fluoxetine Flupirtine Hopantenic acid Lanthanum Lavender oil Lignans (e.g., 4-O-methylhonokiol , honokiol , magnolol , obovatol )Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Nicotinamide (niacinamide) Org 25,435 Phenytoin Propanidid Retigabine (ezogabine) Safranal Seproxetine Stiripentol Sulfonylalkanes (e.g., sulfonmethane (sulfonal) , tetronal , trional )Terpenoids (e.g., borneol )Topiramate Valerian constituents (e.g., isovaleric acid , isovaleramide , valerenic acid , valerenol )
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