Chemistry:1DD-LSD

From HandWiki

1DD-LSD, also known as 1-dodecanoyl-LSD or as SYN-L-004, is an acylated derivative of lysergic acid diethylamide (LSD). In animal studies, it produces a weak head-twitch response but with 27x lower potency than LSD itself. It is being researched as a potential slow-onset, long lasting prodrug for LSD which is expected to have reduced psychoactive effects.[1][2]

Use and effects

Interactions

Chemistry

Analogues

Analogues of 1DD-LSD include ALD-52 (1A-LSD), 1P-LSD, 1B-LSD, 1H-LSD, and 1V-LSD, among others.

Society and culture

Canada

1DD-LSD is not a controlled substance in Canada as of 2025.[3]

United States

1DD-LSD is not an explicitly controlled substance in the United States.[4] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

References

  1. ↑ "Analytical and behavioral characterization of 1-dodecanoyl-LSD (1DD-LSD)". Drug Testing and Analysis 17 (1): 101–109. April 2024. doi:10.1002/dta.3691. PMID 38569566. 
  2. ↑ Stratford A, Williamson JP, "Prodrugs of Substituted Ergolines", WO patent 2024/028495, published 8 February 2024
  3. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  4. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf 



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