Chemistry:1H-LSD

From HandWiki

1H-LSD, also known as 1-hexanoyl-LSD or as SYN-L-027,[1] is an acylated derivative of lysergic acid diethylamide (LSD), with a six carbon hexanoyl chain attached to the N1 position. It acts as a prodrug for LSD, and in animal studies produces drug-appropriate responding with a similar potency to short-chain homologues such as ALD-52 and 1P-LSD, in contrast to the 4 and 5 carbon homologues 1B-LSD and 1V-LSD which are several times weaker.[2]

Use and effects

1H-LSD produces similar effects to LSD with a shorter metabolic half-life. There are no documented cases of it being used recreationally.[3]

Interactions

Chemistry

Analogues

Analogues of 1H-LSD include ALD-52 (1A-LSD), 1P-LSD, 1cP-LSD, 1DD-LSD, 1cP-AL-LAD, and 1P-ETH-LAD, among others.

See also

  • Substituted lysergamide
  • Lizard Labs

References

  1. ↑ Stratford A, Williamson JP, "Prodrugs of Substituted Ergolines", WO patent 2024028495, published 8 February 2024
  2. ↑ "Analytical and behavioral characterization of 1-hexanoyl-LSD (1H-LSD)". Drug Testing and Analysis 17 (4): 561–569. July 2024. doi:10.1002/dta.3767. PMID 38965834. PMC 11994379. https://researchonline.ljmu.ac.uk/id/eprint/23720/1/Analytical%20and%20behavioral%20characterization%20of%201%E2%80%90hexanoyl%E2%80%90LSD%20%201H%E2%80%90LSD.pdf. 
  3. ↑ "Analytical and behavioral characterization of 1-hexanoyl-LSD (1H-LSD)". Drug Testing and Analysis 17 (4): 561–569. April 2025. doi:10.1002/dta.3767. PMID 38965834. 



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