Chemistry:1H-LSD

From HandWiki

1H-LSD, also known as 1-hexanoyl-LSD or as SYN-L-027,[1] is an acylated derivative of lysergic acid diethylamide (LSD), with a six carbon hexanoyl chain attached to the N1 position.[2] It acts as a prodrug for LSD, and in animal studies produces drug-appropriate responding with a similar potency to short-chain homologues such as ALD-52 and 1P-LSD, in contrast to the 4 and 5 carbon homologues 1B-LSD and 1V-LSD which are several times weaker.[3]

Use and effects

1H-LSD produces similar effects to LSD with a shorter metabolic half-life. There are no documented cases of it being used recreationally.[4]

Interactions

Chemistry

Analogues

Analogues of 1H-LSD include ALD-52 (1A-LSD), 1P-LSD, 1cP-LSD, 1DD-LSD, 1cP-AL-LAD, and 1P-ETH-LAD, among others.

Society and culture

Canada

1H-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.[5]

United States

1H-LSD is not an explicitly controlled substance in the United States.[6] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

References

  1. ↑ Stratford A, Williamson JP, "Prodrugs of Substituted Ergolines", WO patent 2024/028495, published 8 February 2024
  2. ↑ "1H-LSD" (in ru). https://aipsin.com/newsubstance/1735/. 
  3. ↑ "Analytical and behavioral characterization of 1-hexanoyl-LSD (1H-LSD)". Drug Testing and Analysis 17 (4): 561–569. July 2024. doi:10.1002/dta.3767. PMID 38965834. PMC 11994379. https://researchonline.ljmu.ac.uk/id/eprint/23720/1/Analytical%20and%20behavioral%20characterization%20of%201%E2%80%90hexanoyl%E2%80%90LSD%20%201H%E2%80%90LSD.pdf. 
  4. ↑ "Analytical and behavioral characterization of 1-hexanoyl-LSD (1H-LSD)". Drug Testing and Analysis 17 (4): 561–569. April 2025. doi:10.1002/dta.3767. PMID 38965834. 
  5. ↑ "Controlled Drugs and Substances Act". 5 December 2025. https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  6. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:1H-LSD&oldid=4242890"