Chemistry:Danitracen

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Danitracen (WA 335) is an antidepressant compound developed in the 1970s. Danitracen acts by blocking central and peripheral 5-HT receptors: it potentiates testosterone-induced sexual behavior in rats and abolishes the 5-hydroxytryptophan (5-HTP) induced hypermotility in mice. In amphetamine-treated rats, administration of danitracen lowered whole brain serotonin and norepinephrine levels. Danitracen was investigated in clinical trials in depressed patients. At 3 mg/day, danitracen was equipotent to 150 mg/day amitriptyline.[1][2][3][4][5][6]

See also

References

  1. ↑ "[On the pharmacology of 9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (WA 335), a histamine and serotonin antagonist (author's transl)]" (in German). Arzneimittel-Forschung 25 (11): 1723–37. November 1975. PMID 1049. 
  2. ↑ "Danitracen". Inxight Drugs. National Center for Advancing Translational Sciences (NCATS). https://drugs.ncats.io/drug/SD507F5T2W. 
  3. ↑ "Danitracen". Drugs of the Future 1 (6)): 279. 1976. doi:10.1358/dof.1976.001.06.1002525. 
  4. ↑ "The action of compound WA-335 on the central nervous system". Archivum Immunologiae et Therapiae Experimentalis 24 (2): 205–22. 1976. PMID 945051. 
  5. ↑ "Influence of WA-335, a factor which blocks serotonin receptors, on neuroleptic-induced catalepsy". Archivum Immunologiae et Therapiae Experimentalis 24 (2): 197–203. 1976. PMID 945050. 
  6. ↑ "[Comparison of the effects of the anthracene derivative danitracen (WA335-BS) and amitriptyline in depressive patients (author's transl)]" (in German). Arzneimittel-Forschung 26 (6): 1160–2. 1976. PMID 786311. 

Attribution: some content on this page was copied from the public domain source https://drugs.ncats.io/drug/SD507F5T2W.

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