Chemistry:FG-8205
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Short description: Chemical compound
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| Formula | C17H16ClN5O2 |
| Molar mass | 357.80 g·mol−1 |
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FG-8205[1] (L-663,581) is an imidazobenzodiazepine derivative related to bretazenil, which acts as a partial agonist at GABAA receptors, with slight selectivity for the α1-containing subtype. In animal tests it has anxiolytic and anticonvulsant effects but with little sedation or ataxia produced.[2][3][4][5]
See also
References
- ↑ "Novel benzodiazepine receptor partial agonists: oxadiazolylimidazobenzodiazepines". J. Med. Chem. 32 (10): 2282–91. October 1989. doi:10.1021/jm00130a010. PMID 2552115.
- ↑ "The pharmacological properties of the imidazobenzodiazepine, FG 8205, a novel partial agonist at the benzodiazepine receptor". Br. J. Pharmacol. 101 (3): 753–61. November 1990. doi:10.1111/j.1476-5381.1990.tb14152.x. PMID 1963808.
- ↑ "Blood–brain barrier permeability and in vivo activity of partial agonists of benzodiazepine receptor: a study of L-663,581 and its metabolites in rats". J. Pharmacol. Exp. Ther. 271 (3): 1197–202. December 1994. PMID 7996426.
- ↑ "Contextual fear conditioning and baseline startle responses in the rat fear-potentiated startle test: a comparison of benzodiazepine/gamma-aminobutyric acid-A receptor agonists". Behav Pharmacol 11 (6): 495–504. September 2000. doi:10.1097/00008877-200009000-00006. PMID 11103915.
- ↑ Atack JR (August 2003). "Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site". Curr Drug Targets CNS Neurol Disord 2 (4): 213–32. doi:10.2174/1568007033482841. PMID 12871032.
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