Chemistry:Kenazepine
Kenazepine is a benzodiazepine containing a functional alkylating moiety.[1] The chemical formula is C
19H
16BrClFN
3O
2.[2]
Uses
The compound functions as a research tool in pharmacology. It binds irreversibly and non-competitively to some brain benzodiazepine receptors and competitively to others, providing evidence for the existence of different receptor populations within the central nervous system. Kenazepine exhibits long-lasting anticonvulsant effects, likely due to its irreversible binding mechanism, and is used to study the heterogeneity and function of benzodiazepine receptors.[3]
Studies show that kenazepine provides a long-lasting protection against convulsions caused by pentylenetetrazole in vivo, suggesting a similar irreversible binding mechanism in the body.[2]
References
- ↑ "Benzodiazepine receptors in the central nervous system". International Review of Neurobiology 23: 103–140 (115). 1982. doi:10.1016/S0074-7742(08)60623-6. ISBN 978-0-12-366823-3. PMID 6288605. "Kenazepine , a derivative of the benzodiazepine Ro 7/1986 has a bromoacetyl moiety that can react with binucleophiles such as SH and - NH2.".
- ↑ 2.0 2.1 "In vivo effects of two novel alkylating benzodiazepines, irazepine and kenazepine". Pharmacology, Biochemistry, and Behavior 14 (4): 487–91. April 1981. doi:10.1016/0091-3057(81)90307-5. PMID 7232472.
- ↑ "Heterogeneity of Benzodiazepine Receptors in the Central Nervous System Demonstrated with Kenazepine, an Alkylating Benzodiazepine" (in en). Journal of Neurochemistry 35 (3): 591–597. 1980. doi:10.1111/j.1471-4159.1980.tb03695.x. ISSN 1471-4159. PMID 6256492. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.1980.tb03695.x. Retrieved 14 September 2025.
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