Chemistry:Lysergic acid tert-butylamide

From HandWiki

LAtB
Clinical data
Other namesLAtB; N-tert-Butyllysergamide; NtB-LA
Drug classSerotonin receptor modulator; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
PubChem CID
Chemical and physical data
FormulaC20H25N3O
Molar mass323.440 g·mol−1
3D model (JSmol)

Lysergic acid tert-butylamide (LAtB), also known as N-tert-butyllysergamide (NtB-LA), is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2][3] It was described in an early patent as reportedly being psychoactive and hallucinogenic and as producing hypothermia and "anti-hypothalamic" effects presumably in animals.[2] The drug shows activity at serotonin receptors, but is a very low-potency agonist of the serotonin 5-HT2A receptor.[1] The chemical synthesis of LAtB has been described[2] and analytical characterization has been described.[3] It was first described in the literature in a patent by Richard P. Pioch at Eli Lilly and Company in 1961 (filed in 1956).[2] The drug's pharmacology was later studied by David E. Nichols and colleagues.[1]

See also

References

  1. ↑ 1.0 1.1 1.2 Chemistry and Structure-Activity Relationships of Psychedelics. Current Topics in Behavioral Neurosciences. 36. 2018. pp. 1–43. doi:10.1007/7854_2017_475. ISBN 978-3-662-55878-2. https://bitnest.netfirms.com/external/10.1007/7854_2017_475. 
  2. ↑ 2.0 2.1 2.2 2.3 Pioch RP, "Lysergic acid amides", US patent 2997470, issued 1961-08-22
  3. ↑ 3.0 3.1 "The Differentiation of Lysergic Acid Diethylamide (LSD) from N -Methyl- N -Propyl and N -Butyl Amides of Lysergic Acid". Journal of Forensic Sciences 34 (3): 532–546. 1 May 1989. doi:10.1520/JFS12674J. ISSN 0022-1198. https://dl.astm.org/jofs/article/34/3/532/9242/The-Differentiation-of-Lysergic-Acid-Diethylamide. Retrieved 15 October 2025. 



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