Chemistry:Pitrazepin

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Short description: Chemical compound
Pitrazepin
Pitrazepin-ifa.png
Clinical data
Pregnancy
category
  • ?
Routes of
administration		?
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC19H19N5
Molar mass317.396 g·mol−1
3D model (JSmol)

Pitrazepin is a competitive GABAA and glycine receptor antagonist.[1][2][3] It has been used to study insect and snail nervous systems in scientific research.[4][5][6][7][8][9]

See also

References

  1. ↑ "Pitrazepin, a novel GABAA antagonist". Neuroscience Letters 45 (3): 311–6. April 1984. doi:10.1016/0304-3940(84)90244-1. PMID 6328380. 
  2. ↑ "Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors". European Journal of Pharmacology 118 (1–2): 115–21. November 1985. doi:10.1016/0014-2999(85)90669-7. PMID 3002806. 
  3. ↑ "Pitrazepin: a central glycine and GABA antagonist". European Journal of Pharmacology 131 (2–3): 311–3. November 1986. doi:10.1016/0014-2999(86)90590-X. PMID 3816960. 
  4. ↑ "GABA receptor molecules of insects". Exs 63: 172–209. 1993. doi:10.1007/978-3-0348-7265-2_8. ISBN 978-3-0348-7267-6. PMID 7678525. 
  5. ↑ "GABA receptors on the cell-body membrane of an identified insect motor neuron". Proceedings of the Royal Society B 232 (1269): 443–56. January 1988. doi:10.1098/rspb.1988.0006. PMID 2451252. Bibcode: 1988RSPSB.232..443S. 
  6. ↑ "The action of GABA receptor agonists and antagonists on muscle membrane conductance in Schistocerca gregaria". British Journal of Pharmacology 95 (3): 713–22. November 1988. doi:10.1111/j.1476-5381.1988.tb11697.x. PMID 2850061. 
  7. ↑ "Pharmacologic characteristics of excitatory gamma-amino-butyric acid (GABA) receptors in a snail neuron". General Pharmacology 28 (1): 45–53. January 1997. doi:10.1016/S0306-3623(96)00152-8. PMID 9112076. 
  8. ↑ "Pharmacological characteristics of two different types of inhibitory GABA receptors on Achatina fulica neurones". European Journal of Pharmacology 182 (1): 49–62. June 1990. doi:10.1016/0014-2999(90)90492-O. PMID 2169426. 
  9. ↑ Takeuchi H (September 1992). "Sensitivities of Achatina giant neurones to putative amino acid neurotransmitters". Comparative Biochemistry and Physiology C 103 (1): 1–12. doi:10.1016/0742-8413(92)90219-w. PMID 1360362. 

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See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

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