Chemistry:Butopamine
From HandWiki
Butopamine (INN, USAN; developmental code name LY-131126; also known as (R,R)-ractopamine) is a sympathomimetic agent, β-adrenergic receptor agonist, and positive inotrope of the phenethylamine family which was studied for treatment of heart failure but was never marketed.[1][2][3][4] It is an analogue of dobutamine[3][4] and is the (R,R)-enantiomer of ractopamine.[2] Butopamine is not a catecholamine and is resistant to metabolism by catechol O-methyltransferase (COMT).[3] In contrast to dobutamine, butopamine is orally active.[3] In addition to its positive inotropic effects, butopamine has positive chronotropic effects.[3]
References
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. 2014. p. 199. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA199. Retrieved 27 February 2025.
- ↑ 2.0 2.1 Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. 2012. p. 58. ISBN 978-94-011-4439-1. https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA58. Retrieved 27 February 2025.
- ↑ 3.0 3.1 3.2 3.3 3.4 Annual Reports in Medicinal Chemistry. Academic Press. 1981. p. 96. ISBN 978-0-08-058360-0. https://books.google.com/books?id=LVISmUSjD0cC&pg=PA96. Retrieved 27 February 2025.
- ↑ 4.0 4.1 "Recent advances in the management of chronic heart failure". Prim Care 12 (1): 117–142. March 1985. doi:10.1016/S0095-4543(21)01244-6. PMID 3846305.
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