Chemistry:Thiethylperazine
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| Trade names | Torecan, Norzine |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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| Protein binding | 60% |
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| Formula | C22H29N3S2 |
| Molar mass | 399.62 g·mol−1 |
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Thiethylperazine (Torecan, Norzine) is an antiemetic[1] of the phenothiazine class. It is an antagonist of dopamine receptors (DRD1, DRD2, DRD4) as well as of 5-HT2A, 5-HT2C receptors, mAChRs (1 through 5), α1 adrenergic receptor and H1 receptor.
Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.[2]
Pharmacokinetics
Distribution
This drug is highly lipofilic and it binds with membranes and serum proteins (over 85%). It accumulates in organs with high blood flow and penetrates the placenta. It cannot be removed with dialysis.
Metabolism
It is mainly metabolised in the liver and only 3% is eliminated unchanged. Torecan's half-life is 12 h.
Teratogenicity
In toxic doses above the terapeutic window, it increases the rate of cleft palate occurrence.
Antipsychotic activity
Theithylperazine may possess antipsychotic activity[4] due to the antagonism of 5-HT2 and D2 receptors. It can cause extrapyramidal symptoms.[citation needed] Nevertheless, it was never marketed as an antipsychotic.
One cause of acute dystonia occurred in a 19-year-old male patient after discontinuation of this drug.[5]
Overdose
Signs of acute thiethylperazine overdose include: extrapyramidal symptoms, confusion, convulsions, respiratory depression and hypotension.
Synthesis
Goldberg reaction between 3-(ethylsulfanyl)aniline [1783-82-0] (1) and 2-chlorobenzoic acid [118-91-2] (2) to give the diarylamine, CID:82254530 (3). The carboxyl in the anthranilic acid residue, having performed its activating function, is then thermolytically removed to form [68083-49-8] (4). Upon treatment with sulfur and iodine, we get predominantly the phenothiazine [46815-10-5] (5); The rxn may well be aided by the presence of the electron donating thioether at the para-position. Alkylation with 1-(ɣ̞-chloropropyl)-4-methylpiperazine [104-16-5] (6) in the presence of sodamide affords Thiethylperazine (7).
References
- ↑ "The Effects of Thiethylperazine Dimaleate (Torecan) on Nausea and Vomiting". Canadian Medical Association Journal 92 (8): 422–423. February 1965. PMID 14261157.
- ↑ "Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice". The Journal of Clinical Investigation 121 (10): 3924–3931. October 2011. doi:10.1172/JCI57867. PMID 21881209.
- "Alzheimer disease: Transport protein ABCC1 plays key role in clearing beta-amyloid from brains of mice". ScienceDaily (Press release). September 1, 2011.
- ↑ "Charakterystyka Produktu Leczniczego" (in pl). https://rejestrymedyczne.ezdrowie.gov.pl/api/rpl/medicinal-products/6729/characteristic.
- ↑ "Thiethylperazine; clinical antipsychotic efficacy and correlation with potency in predictive systems". Archives of General Psychiatry 35 (9): 1112–1118. September 1978. doi:10.1001/archpsyc.1978.01770330086008. PMID 99115.
- ↑ "Recurrent dystonic reactions induced by thiethylperazine". Drug Intelligence & Clinical Pharmacy 19 (7–8): 550–551. July 1985. doi:10.1177/106002808501900708. PMID 4028959.
- ↑ "Synthesen auf dem Phenothiazin-Gebiet. 1. Mitteilung. Mercaptophenothiazin-Derivate.". Helvetica Chimica Acta 41 (4): 1061–1072. 1958. doi:10.1002/hlca.19580410419.
- ↑ "Synthesen auf dem Phenothiazin-Gebiet. 2. Mitteilung. N-substituierte Mercaptophenothiazin-Derivate.". Helvetica Chimica Acta 41 (4): 1072–1108. 1958. doi:10.1002/hlca.19580410420.
- ↑ Jany R, Bourquin jP, Gamboni G, Schwarb G, US patent 3336197, issued 1967, assigned to Sandoz KK.
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