Chemistry:Phenprobamate
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Short description: Chemical compound
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| Elimination half-life | 5 - 8 hours |
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| Formula | C10H13NO2 |
| Molar mass | 179.22 g·mol−1 |
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Phenprobamate (Gamaquil, Isotonil, Actozine) is a centrally acting skeletal muscle relaxant, with additional sedative and anticonvulsant effects.[1] Overdose is similar to barbiturates. Its mechanism of action is probably similar to meprobamate. Phenprobamate has been used in humans as an anxiolytic, and is still sometimes used in general anesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some European countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolized by oxidative degradation of the carbamate group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.
Doses range from 400 to 800 mg, up to 3 times a day.
References
- ↑ "Phenprobamate dependence: a case report". Addictive Behaviors 45: 232–3. June 2015. doi:10.1016/j.addbeh.2015.01.037. PMID 25727392.
Further reading
- "Haemoperfusion may be useful in phenprobamate and polypharmacy intoxication of paediatric patients". Nephrology, Dialysis, Transplantation 17 (5): 941. May 2002. doi:10.1093/ndt/17.5.941. PMID 11981094.
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