Chemistry:Pivenfrine
From HandWiki
Pivenfrine (INN), also known as pivalylphenylephrine or phenylephrine pivalate, is a sympathomimetic and mydriatic agent which was never marketed.[1][2][3][4] It is the 3-pivalyl ester of phenylephrine.[1] Pivenfrine has much greater lipophilicity than phenylephrine.[5] Higher lipophilicity is known to greatly improve corneal permeability, as in dipivefrine (epinephrine dipivalate).[6] Another related compound is etilefrine pivalate (ethylnorphenylephrine pivalate).[1]
References
- ↑ 1.0 1.1 1.2 Elks, J. (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. pp. 61,1001. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA1001. Retrieved 2024-09-01.
- ↑ Dictionary of Pharmacological Agents. CRC Press. 21 November 1996. pp. 615–. ISBN 978-0-412-46630-4. https://books.google.com/books?id=Z_mfTTIApVEC&pg=PA615.
- ↑ World Health Organization (2000). International Nonproprietary Names (INN) for Pharmaceutical Substances. World Health Organization. ISBN 978-0-11-986227-0. https://books.google.com/books?id=HcogPwAACAAJ.
- ↑ Essentials of medicinal chemistry. John Wiley & Sons, Incorporated. 1988. ISBN 978-0-471-88356-2. https://books.google.com/books?id=6hxtAAAAMAAJ.
- ↑ "Pivenfrine". https://pubchem.ncbi.nlm.nih.gov/compound/130545.
- ↑ "Ophthalmic drug dosage forms: characterisation and research methods". ScientificWorldJournal 2014. 2014. doi:10.1155/2014/861904. PMID 24772038.
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