Chemistry:5-MeO-MBT

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5-MeO-MBT, also known as 5-methoxy-N-methyl-N-butyltryptamine, is a serotonin receptor modulator of the tryptamine and 5-methoxytryptamine families related to 5-MeO-DMT.[1]

The drug was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved) and its properties and effects in humans are unknown.[2]

It shows affinity for the serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors (Ki = 10 nM, 721 nM, and 252 nM, respectively).[1] The drug is a partial agonist of the serotonin 5-HT2A receptor (EC50 = 1,318 nM; Emax = 38–47%).[1] Its affinities for the serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors were similar to those of 5-MeO-DMT, and it showed only 1.8-fold lower activational potency at the serotonin 5-HT2A receptor, but it had much lower efficacy in activating the receptor in comparison (Emax = 38–47% and 98%, respectively).[1]

The chemical synthesis of 5-MeO-MBT has been described.[1] 5-MeO-MBT has several possible positional isomers, including 5-MeO-MiBT, 5-MeO-MsBT, and 5-MeO-MtBT.[3]

5-MeO-MBT was first described in the scientific literature by Niels Jensen in 2004.[1]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Jensen N (2004). Tryptamines as Ligands and Modulators of the Serotonin 5-HT2A Receptor and the Isolation of Aeruginascin from the Hallucinogenic Mushroom Inocybe aeruginascens (PhD thesis). Georg-August-Universität zu Göttingen.
  2. ↑ Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252. http://www.erowid.org/library/books_online/tihkal/tihkal.shtml. 
  3. ↑ "5-MeO-MsBT (5-methoxy-N-methyl-N-secbutyltryptamine)" (in ru). https://aipsin.com/newsubstance/987/. 



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