Chemistry:DPI-3290
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Short description: Chemical compound
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| Formula | C30H34FN3O2 |
| Molar mass | 487.619 g·mol−1 |
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DPI-3290 was discovered by scientists at Burroughs Wellcome and licensed to Delta Pharmaceutical [1] and is a drug that is used in scientific research. It is a potent analgesic drug,[2] which produces little respiratory depression.[3]
DPI-3290 acts as an agonist at both μ- and δ-opioid receptor, with an IC50 of 6.2nM at μ and 1.0nM at δ.[4]
See also
References
- ↑ US Patent 5552404 - Opioid compounds and methods for using same
- ↑ "DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity". The Journal of Pharmacology and Experimental Therapeutics 307 (3): 1221–6. December 2003. doi:10.1124/jpet.103.054361. PMID 14534368.
- ↑ "DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function". The Journal of Pharmacology and Experimental Therapeutics 307 (3): 1227–33. December 2003. doi:10.1124/jpet.103.054429. PMID 14534367.
- ↑ "Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics". The AAPS Journal 8 (1): E118-25. March 2006. doi:10.1208/aapsj080114. PMID 16584118.
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