Chemistry:4-AcO-MPT

From HandWiki

4-AcO-MPT, also known as 4-acetoxy-N-methyl-N-propyltryptamine, is a psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to 4-AcO-DMT (psilacetin).[1][2][3][4][5] It is thought to act as a prodrug of 4-HO-MPT and hence is believed to act as a non-selective serotonin receptor agonist including of the serotonin 5-HT2A receptor.[3][4] The drug produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents,[4] and was first encountered as a novel designer drug in 2018.[1] 4-AcO-MPT was first described in the scientific literature by at least 2017.[2]

Use and effects

Interactions

Chemistry

Analogues

Analogues of 4-AcO-MPT include methylpropyltryptamine (MPT), 4-HO-MPT (meprocin), 5-MeO-MPT, 4-AcO-DMT (psilacetin), 4-AcO-MET (metacetin), 4-AcO-MiPT (mipracetin), and 4-AcO-DPT (depracetin), among others.

Society and culture

Canada

4-AcO-MPT is not a controlled substance in Canada as of 2025.[6]

Sweden

4-AcO-MPT is a controlled substance in Sweden.[7]

See also

References

  1. ↑ 1.0 1.1 "4-AcO-MPT" (in ru). https://aipsin.com/newsubstance/169/. 
  2. ↑ 2.0 2.1 PeakAL: Protons I Have Known and Loved, Too — Another Fifty Shades of Grey-Market Spectra (Report). 31 December 2017. doi:10.16889/isomerdesign-5. https://isomerdesign.com/doi/5/10.16889-isomerdesign-5.pdf. Retrieved 11 October 2025. 
  3. ↑ 3.0 3.1 "4-Hydroxy-N,N-methylpropyltryptamine (4-OH-MPT) in vitro human metabolism". Toxicologie Analytique et Clinique 34 (3): S96. 2022. doi:10.1016/j.toxac.2022.06.147. Bibcode: 2022ToxAC..34Q..96B. 
  4. ↑ 4.0 4.1 4.2 "Investigation of the Structure-Activity Relationships of Psilocybin Analogues". ACS Pharmacology & Translational Science 4 (2): 533–542. April 2021. doi:10.1021/acsptsci.0c00176. PMID 33860183. 
  5. ↑ "Receptor Binding Profiles for Tryptamine Psychedelics and Effects of 4-Propionoxy-N,N-dimethyltryptamine in Mice". ACS Pharmacology & Translational Science 6 (4): 567–577. April 2023. doi:10.1021/acsptsci.2c00222. PMID 37082754. 
  6. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  7. ↑ "4-AcO-MPT" (in ru). https://aipsin.com/newsubstance/306/. 



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