Chemistry:Estradiol hemisuccinate
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Short description: Chemical compound
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| Trade names | Eutocol, Hosterona (with progesterone) |
| Other names | Estradiol succinate; Estradiol 17β-hemisuccinate; Estradiol 17β-succinate |
| Routes of administration | By mouth, intramuscular injection |
| Drug class | Estrogen; Estrogen ester |
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| Formula | C22H28O5 |
| Molar mass | 372.461 g·mol−1 |
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Estradiol hemisuccinate (brand name Eutocol), or simply estradiol succinate, also known as estradiol 17β-hemisuccinate, is an estrogen medication and an estrogen ester – specifically, the hemisuccinate ester of estradiol.[1] It is used as a component of hormone replacement therapy for menopause.[2] Like other estrogens, estradiol hemisuccinate has been found to have beneficial effects on the skin, with improvement of skin thickness observed.[2][3]
Estradiol hemisuccinate is also a component of estradiol hemisuccinate/progesterone (brand name Hosterona), an injectable preparation used to induce withdrawal bleeding in women with amenorrhea.[4][5][6]
See also
- Estradiol hemisuccinate/progesterone
- Estriol succinate
- List of estrogen esters § Estradiol esters
References
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. p. 897. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=RA1-PA129.
- ↑ 2.0 2.1 "Biological Effects of Estrogen on Skin". Textbook of Aging Skin. 2010. pp. 361–367 (362). doi:10.1007/978-3-540-89656-2_35. ISBN 978-3-540-89655-5. https://books.google.com/books?id=9-ALWZhXomAC&pg=PA362.
- ↑ "A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness". American Journal of Obstetrics and Gynecology 170 (2): 642–649. February 1994. doi:10.1016/s0002-9378(94)70242-x. PMID 8116726.
- ↑ "¿Qué es Hosterona y para qué sirve?" (in es). matchmyrx.com. PRX Control Solutions. https://matchmyrx.com/es/directorio/marca/hosterona.
- ↑ "Hosterona - Para qué sirve" (in es). Los Medicamentos. 23 November 2012. https://www.losmedicamentos.net/medicamento/hosterona.
- ↑ "HOSTERONA (Hormonoterapia)". Laboratorio GADOR. http://py.mivademecum.com/medicamento-hosterona-id-23974.
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