Chemistry:L-760790

L-760790
Identifiers
	IUPAC name N-benzyl-1-[(3S)-1-[2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl]pyrrolidin-3-yl]methanamine;
PubChem CID	10386282;
ChemSpider	8561724;
ChEMBL	ChEMBL420965;
Chemical and physical data
Formula	C24H28N6
Molar mass	400.530 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(C[C@@H]1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5;
	InChI InChI=1S/C24H28N6/c1-2-4-19(5-3-1)13-25-14-20-8-10-29(16-20)11-9-21-15-26-24-7-6-22(12-23(21)24)30-17-27-28-18-30/h1-7,12,15,17-18,20,25-26H,8-11,13-14,16H2/t20-/m0/s1; Key:JCFDYNJSFCXYRT-FQEVSTJZSA-N;

L-760,790 is an experimental drug from the substituted tryptamine family, which acts as a selective agonist for the 5-HT_1D serotonin receptor, with around 62x selectivity for 5-HT_1D over the closely related 5-HT_1B receptor.^[1]^[2]^[3]^[4]

References

↑ "3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype". Journal of Medicinal Chemistry 40 (22): 3497–3500. October 1997. doi:10.1021/jm9704558. PMID 9357514.
↑ "Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor". Journal of Medicinal Chemistry 42 (4): 677–690. February 1999. doi:10.1021/jm9805687. PMID 10052975.
↑ "3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents". Journal of Medicinal Chemistry 42 (4): 691–705. February 1999. doi:10.1021/jm980569z. PMID 10052976.
↑ "2,7-diazabicyclo[3.3.0]octanes as novel h5-HT receptor agonists". Bioorganic & Medicinal Chemistry Letters 9 (17): 2491–2496. September 1999. doi:10.1016/s0960-894x(99)00409-6. PMID 10498195.

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Identifiers

IUPAC name N-benzyl-1-[(3S)-1-[2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethyl]pyrrolidin-3-yl]methanamine
PubChem CID	10386282
ChemSpider	8561724
ChEMBL	ChEMBL420965
Chemical and physical data
Formula	C₂₄H₂₈N₆
Molar mass	400.530 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN(C[C@@H]1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
InChI InChI=1S/C24H28N6/c1-2-4-19(5-3-1)13-25-14-20-8-10-29(16-20)11-9-21-15-26-24-7-6-22(12-23(21)24)30-17-27-28-18-30/h1-7,12,15,17-18,20,25-26H,8-11,13-14,16H2/t20-/m0/s1 Key:JCFDYNJSFCXYRT-FQEVSTJZSA-N