Chemistry:Norpsilocin

From HandWiki
Short description: Chemical compound
Norpsilocin
Norpsilocin.svg
Clinical data
Other names
  • 4-HO-NMT
  • 4-Hydroxy-N-methyltryptamine
  • AS-63499
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC11H14N2O
Molar mass190.246 g·mol−1
3D model (JSmol)

Norpsilocin (4-HO-NMT) is a tryptamine alkaloid recently discovered in 2017 in the psychedelic mushroom Psilocybe cubensis.[1][2] It is hypothesized to be a dephosphorylated metabolite of baeocystin.[2] Norpsilocin was found to be a near full agonist of the 5-HT2A receptor. It is also more potent than psilocin.[3][4]

See also

References

  1. "Identification of ω-N-Methyl-4-hydroxytryptamine (Norpsilocin) as a Psilocybe Natural Product". Journal of Natural Products 80 (10): 2835–2838. October 2017. doi:10.1021/acs.jnatprod.7b00407. PMID 28929753. 
  2. 2.0 2.1 "Two New Crystalline Forms of Norpsilocin". https://psychedelicreview.com/two-new-crystalline-forms-of-norpsilocin/. 
  3. "Study Finds Norpsilocin is More Potent Than Psilocin at 5-HT2A". https://psychedelicreview.com/event/study-finds-norpsilocin-is-more-potent-than-psilocin-at-5-ht2a/. 
  4. "Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin". Journal of Natural Products 83 (2): 461–467. February 2020. doi:10.1021/acs.jnatprod.9b01061. PMID 32077284.