Chemistry:2MePI

From HandWiki

2MePI, also known as 2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole, is a serotonin receptor modulator of the pyridoindole (γ-carboline) family.[1] It is the pyridoindole homologue of the ibogalog (azepinoindole) ibogaminalog (DM-506).[1]

The drug acts as a weak partial agonist or functional competitive antagonist of the serotonin 5-HT2A receptor, with an affinity (Ki) of 95 nM, an EC50 (Emax) of 533 nM (32%), an apparent IC50 of 3,100 to 18,000 nM, and a KB of 89 to 228 nM.[1] Compared to ibogaminalog, 2MePi had 5-fold lower affinity, 59-fold lower activational potency, and less than half the activational efficacy at the serotonin 5-HT2A receptor.[1] Results were analogous for 8MeO-2MePI against ibogainalog (8MeO-2MePI's ibogalog homologue).[1] These findings indicate that ibogalogs are the more optimal structural scaffold for serotonin 5-HT2A receptor agonism.[1]

2MePI was first described in the scientific literature by Matthias Liechti and colleagues in 2026.[1]

Chemical structures of 2MePI and related compounds

See also

  • Substituted γ-carboline
  • Pyridopyrroloquinoxaline § Related compounds
  • Tiflucarbine

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "Ibogalogs Activate the 5-HT2A Receptor through a Mechanism Involving Outward and Inward Movements of the Respective Transmembrane Segment TM6 and TM7". Neurochemical Research 51 (2). March 2026. doi:10.1007/s11064-026-04727-5. PMID 41870698. 



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